EIF2B2 and EIF2B4

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		EIF2B2	EIF2B4
Description		eukaryotic translation initiation factor 2B subunit beta	eukaryotic translation initiation factor 2B subunit delta
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Animal Organ Development T Cell Receptor Signaling Pathway	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Animal Organ Development T Cell Receptor Signaling Pathway
Pathways		Recycling of eIF2:GDP	Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Coronary artery disease ( 33020668) Gastroesophageal reflux disease ( 34187846) Mood instability ( 29187730) Serum alkaline phosphatase levels ( 33547301) Youthful appearance (self-reported) ( 32339537)	Non-oily fish consumption ( 32066663)
Interacting Genes		12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 PCGF6 TET2	3 interacting genes: EIF2B2 EIF2S1 EIF2S2
Entrez ID		8892	8890
HPRD ID		05923	09459
Ensembl ID		ENSG00000119718	ENSG00000115211
Uniprot IDs		P49770 Q53XC2	B4DUP5 E7ERK9 F8W8L6 Q71US4 Q9HBP7 Q9UI10
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Glial Cell Development Translational Initiation Response To Heat Oligodendrocyte Development T Cell Receptor Signaling Pathway Cytoplasmic Translational Initiation Main Axon Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Translation Cellular Response To Manganese Ion Guanyl-nucleotide Exchange Factor Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Manganese Ion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Translational Initiation Regulation Of Primary Metabolic Process Regulation Of Translation In Response To Stress Translation Immune Response-activating Signaling Pathway Response To Glucose Translation Initiation Factor Binding Response To Monosaccharide PcG Protein Complex Ephrin Receptor Binding Immune Response-regulating Signaling Pathway Response To Carbohydrate Activation Of Immune Response Stress Granule Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Biosynthetic Process Ovarian Follicle Development Positive Regulation Of Translational Initiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Endoplasmic Reticulum Stress Translation Initiation Ternary Complex	Translation Initiation Factor Activity Translational Initiation Eukaryotic Translation Initiation Factor 2 Complex Translation Cytoplasmic Translational Initiation Response To Heat Regulation Of Translational Initiation Translation Initiation Ternary Complex Response To Temperature Stimulus Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Male Germ Cell Proliferation Macromolecule Biosynthetic Process Response To Kainic Acid Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Eukaryotic Translation Initiation Factor 2B Complex HRI-mediated Signaling Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mitochondrial Respirasome Assembly Regulation Of Translational Initiation In Response To Stress Regulation Of Translation Cellular Response To Manganese Ion Formation Of Translation Preinitiation Complex PERK-mediated Unfolded Protein Response Response To Manganese Ion Eukaryotic 48S Preinitiation Complex Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Translation In Response To Stress Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Oligodendrocyte Development Protein Metabolic Process Stress Granule Assembly ER-nucleus Signaling Pathway Integrated Stress Response Signaling Negative Regulation Of Translational Initiation Ovarian Follicle Development Synapse Cellular Response To Heat Regulation Of Epithelial Cell Apoptotic Process Mitophagy Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Endoplasmic Reticulum Unfolded Protein Response Glial Cell Development Autophagy Of Mitochondrion Ribosome Binding
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