EIF2B2 and EIF2B5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro)

		EIF2B2	EIF2B5
Description		eukaryotic translation initiation factor 2B subunit beta	eukaryotic translation initiation factor 2B subunit epsilon
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Animal Organ Development T Cell Receptor Signaling Pathway	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translation Positive Regulation Of Translational Initiation Astrocyte Differentiation T Cell Receptor Signaling Pathway
Pathways		Recycling of eIF2:GDP	Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Coronary artery disease ( 33020668) Gastroesophageal reflux disease ( 34187846) Mood instability ( 29187730) Serum alkaline phosphatase levels ( 33547301) Youthful appearance (self-reported) ( 32339537)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 27863252 32888494) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 PCGF6 TET2	13 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B RNF10 STX11
Entrez ID		8892	8893
HPRD ID		05923	04898
Ensembl ID		ENSG00000119718	ENSG00000145191
Uniprot IDs		P49770 Q53XC2	A0A3B3ISX3 Q13144
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ	3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Glial Cell Development Translational Initiation Response To Heat Oligodendrocyte Development T Cell Receptor Signaling Pathway Cytoplasmic Translational Initiation Main Axon Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Translation Cellular Response To Manganese Ion Guanyl-nucleotide Exchange Factor Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Manganese Ion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Translational Initiation Regulation Of Primary Metabolic Process Regulation Of Translation In Response To Stress Translation Immune Response-activating Signaling Pathway Response To Glucose Translation Initiation Factor Binding Response To Monosaccharide PcG Protein Complex Ephrin Receptor Binding Immune Response-regulating Signaling Pathway Response To Carbohydrate Activation Of Immune Response Stress Granule Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Biosynthetic Process Ovarian Follicle Development Positive Regulation Of Translational Initiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Endoplasmic Reticulum Stress Translation Initiation Ternary Complex	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-catenin Destruction Complex Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Tau-protein Kinase Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Wnt Signaling Pathway Viral Protein Processing Regulation Of Glycogen Biosynthetic Process ATP Binding Protein Kinase CK2 Complex Negative Regulation Of Signal Transduction Cytoplasmic Translational Initiation Macromolecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Glycogen Metabolic Process Regulation Of Glycogen (starch) Synthase Activity Viral Process Tau Protein Binding Regulation Of Autophagy Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Autophagy Regulation Of Amyloid Precursor Protein Catabolic Process Transferase Activity Negative Regulation Of Intracellular Signal Transduction Cellular Response To Interleukin-3 Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?