C9orf72 and POP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C9orf72	POP7
Description		C9orf72-SMCR8 complex subunit	POP7 ribonuclease P/MRP subunit
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GO Annotations	Cellular Component	P-body Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Membrane Axon Dendrite Growth Cone Cytoplasmic Vesicle Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Cell Projection Neuron Projection Perikaryon Axonal Growth Cone Main Axon Autolysosome Synapse Flemming Body Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol Atg1/ULK1 Kinase Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Cytoplasm Multimeric Ribonuclease P Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleic Acid Binding RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Regulation Of Protein Localization Stress Granule Assembly Negative Regulation Of Exocytosis Axon Extension Negative Regulation Of Immune Response Autophagosome-lysosome Fusion Regulation Of Synaptic Vesicle Cycle Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly	TRNA 5'-leader Removal RRNA Processing RNA Processing TRNA Processing
Pathways			tRNA processing in the nucleus
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19734901 20801718 22959728 24931836 25442119 27455348 29566793 30976013) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Low density lipoprotein cholesterol levels ( 32154731) Medication use (thyroid preparations) ( 31015401) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 27863252 32888494) Schizophrenia ( 30285260)
Interacting Genes		11 interacting genes: APP COIL CRX EIF2B2 HMG20A POP7 REL SRPK1 SYN3 TRIM73 VRTN	11 interacting genes: AKT1 APP C9orf72 FOXP1 HSPB1 LAGE3 RPP25 RPP25L RPP38 RPP40 SMN1
Entrez ID		203228	10248
HPRD ID		12975	09357
Ensembl ID		ENSG00000147894	ENSG00000172336
Uniprot IDs		Q96LT7	O75817
PDB IDs		6LT0 6V4U 7MGE 7O2W	6AHR 6AHU 6CWX 6LT7
Enriched GO Terms of Interacting Partners?			Ribonuclease MRP Complex TRNA Processing TRNA 5'-leader Removal TRNA 5'-end Processing TRNA Metabolic Process Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity RNA Processing Main Axon RNA Metabolic Process Nucleolar Ribonuclease P Complex Nucleus Regulation Of Interleukin-1 Beta Production Positive Regulation Of Endothelial Cell Migration Regulation Of Interleukin-1 Production Nucleic Acid Metabolic Process Perikaryon Cellular Response To Vascular Endothelial Growth Factor Stimulus RNA Binding Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Nitric Oxide Metabolic Process RRNA Processing Regulation Of Phosphorus Metabolic Process Postsynapse Response To Nerve Growth Factor Positive Regulation Of Cell Motility Cellular Response To Nerve Growth Factor Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Locomotion RRNA Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of TRNA Methylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Ribonuclease MRP Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Macrophage Activation
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