EIF2B2 and EIF2B1

Number of citations of the paper that reports this interaction (PMID 10805739)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EIF2B2	EIF2B1
Gene Name		eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Enzyme Regulator Activity S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Translation Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1	14 interactors: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D CREBBP EIF2B2 EIF2B5 EIF2S1 EIF2S2 GORASP2 MRPL4 RD3 WDYHV1
Entrez ID		8892	1967
HPRD ID		05923	09458
Ensembl ID		ENSG00000119718
Uniprot IDs		P49770 Q53XC2	Q14232
PDB IDs			3ECS
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translation In Response To Stress Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Oligodendrocyte Development Regulation Of Cellular Protein Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process Oligodendrocyte Differentiation Negative Regulation Of Translation Glial Cell Development Neurogenesis Response To Heat Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Glucose Cell Development Positive Regulation Of Hydrolase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Metabolic Process Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Nervous System Development Protein Metabolic Process Regulation Of Catalytic Activity Translation Gliogenesis Cellular Response To Stress Positive Regulation Of Catalytic Activity Central Nervous System Development Ovarian Follicle Development Axon Guidance Positive Regulation Of Translation Reproduction Regulation Of Gene Expression Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Response To Abiotic Stimulus Cell Differentiation Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress	Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Receptor Transactivation Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Regulation Of Smooth Muscle Contraction Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Norepinephrine Secretion Negative Regulation Of Smooth Muscle Contraction Translational Initiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Negative Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase B Activity Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Muscle Contraction Positive Regulation Of Receptor Activity Response To Temperature Stimulus Regulation Of Vasoconstriction Positive Regulation Of Protein Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Translational Initiation Positive Regulation Of Catalytic Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Translational Initiation In Response To Stress Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Translation Regulation Of Translation In Response To Stress Response To Heat Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Reproductive Process Regulation Of Kinase Activity Activation Of MAPK Activity Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Secretion By Cell
Tagcloud ?		actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2	1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Difference) ?		actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2	1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Intersection) ?