EIF2B2 and CCT3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF2B2	CCT3
Gene Name		eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	chaperonin containing TCP1, subunit 3 (gamma)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Plasma Membrane Cell Body Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process Pore Complex Assembly 'de Novo' Posttranslational Protein Folding Toxin Transport
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS			mean corpuscular hemoglobin concentration ( 20139978) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		10 interactors: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1	13 interactors: EIF2B2 FANCA HNRNPA0 HSPA8 MAPK6 MIPOL1 PAFAH1B2 RAF1 SH3BP4 SSSCA1 VAV2 VHL XRCC6
Entrez ID		8892	7203
HPRD ID		05923	08969
Ensembl ID		ENSG00000119718	ENSG00000163468
Uniprot IDs		P49770 Q53XC2	B3KX11 P49368 Q59H77
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translation In Response To Stress Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Oligodendrocyte Development Regulation Of Cellular Protein Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process Oligodendrocyte Differentiation Negative Regulation Of Translation Glial Cell Development Neurogenesis Response To Heat Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Glucose Cell Development Positive Regulation Of Hydrolase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Metabolic Process Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Nervous System Development Protein Metabolic Process Regulation Of Catalytic Activity Translation Gliogenesis Cellular Response To Stress Positive Regulation Of Catalytic Activity Central Nervous System Development Ovarian Follicle Development Axon Guidance Positive Regulation Of Translation Reproduction Regulation Of Gene Expression Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Response To Abiotic Stimulus Cell Differentiation Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress	Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Autophagy Nervous System Development Death-inducing Signaling Complex Assembly Negative Regulation Of Fibril Organization Anatomical Structure Development Response To Stimulus Response To Organic Substance Neurogenesis Axon Guidance Cellular Response To Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Posttranscriptional Regulation Of Gene Expression Female Gonad Development Cell Morphogenesis Response To Heat Development Of Primary Female Sexual Characteristics Cellular Hyperosmotic Salinity Response Regulation Of Fibril Organization Developmental Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Axonogenesis Regulation Of Metabolic Process Clathrin Coat Disassembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To X-ray Chemotaxis Defense Response Neuron Projection Morphogenesis Multicellular Organismal Development Establishment Of Integrated Proviral Latency Response To Temperature Stimulus Negative Regulation Of Cell Proliferation Platelet Activation Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Regulation Of Cell Proliferation Cell Morphogenesis Involved In Differentiation Neurotrophin TRK Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Cellular Response To Stress Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway
Tagcloud ?		actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2	adequately cct5 cct7 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Difference) ?		actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2	adequately cct5 cct7 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Intersection) ?