C9orf72 and SYN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C9orf72	SYN3
Description		C9orf72-SMCR8 complex subunit	synapsin III
Image
GO Annotations	Cellular Component	P-body Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Membrane Axon Dendrite Growth Cone Cytoplasmic Vesicle Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Cell Projection Neuron Projection Perikaryon Axonal Growth Cone Main Axon Autolysosome Synapse Flemming Body Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol Atg1/ULK1 Kinase Complex	Synaptic Vesicle Postsynaptic Density Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Regulation Of Protein Localization Stress Granule Assembly Negative Regulation Of Exocytosis Axon Extension Negative Regulation Of Immune Response Autophagosome-lysosome Fusion Regulation Of Synaptic Vesicle Cycle Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Synaptic Transmission, GABAergic Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Synaptic Vesicle Cycle
Pathways			Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19734901 20801718 22959728 24931836 25442119 27455348 29566793 30976013) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819) Alzheimer's disease progression score ( 29860282) Benign prostatic hyperplasia ( 30988330) Chronic obstructive pulmonary disease ( 30804561) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Heel bone mineral density ( 30598549) Height ( 20881960 21998595 25282103 25429064 31562340) Interleukin-6 levels ( 22205395) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29785010 31959993 30054594 29617998) Metabolite levels ( 23823483) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 31170924) Trunk fat mass adjusted for trunk lean mass ( 32239398)
Interacting Genes		11 interacting genes: APP COIL CRX EIF2B2 HMG20A POP7 REL SRPK1 SYN3 TRIM73 VRTN	8 interacting genes: C9orf72 MORF4L1 MORF4L2 NOS1AP PIAS2 SNCA SYN1 SYN2
Entrez ID		203228	8224
HPRD ID		12975	04083
Ensembl ID		ENSG00000147894	ENSG00000185666
Uniprot IDs		Q96LT7	O14994 Q17R54 Q59EX7
PDB IDs		6LT0 6V4U 7MGE 7O2W	2P0A
Enriched GO Terms of Interacting Partners?			Neurotransmitter Secretion Synaptic Vesicle Cycle Vesicle-mediated Transport In Synapse Neurotransmitter Transport Synaptic Vesicle Clustering Vesicle Localization Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Membrane Synaptic Vesicle Signal Release Regulation Of Exocytosis NuA4 Histone Acetyltransferase Complex Negative Regulation Of Exocytosis Presynapse Synapse Organization Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chemical Synaptic Transmission Response To Desipramine Negative Regulation Of Norepinephrine Uptake Trans-synaptic Signaling Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Synaptic Signaling Synapse Positive Regulation Of DNA Recombination Axon Secretion By Cell Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Neurotransmitter Secretion Regulated Exocytosis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Organelle Localization Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Junction Organization Schaffer Collateral - CA1 Synapse Positive Regulation Of Double-strand Break Repair Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Secretion Negative Regulation Of Chaperone-mediated Autophagy Vesicle-mediated Transport Nucleosome Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Dopamine Metabolic Process Growth Cone
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