C9orf72 and VRTN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C9orf72	VRTN
Description		C9orf72-SMCR8 complex subunit	vertebrae development associated
Image			No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Membrane Axon Dendrite Growth Cone Cytoplasmic Vesicle Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Cell Projection Neuron Projection Perikaryon Axonal Growth Cone Main Axon Autolysosome Synapse Flemming Body Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol Atg1/ULK1 Kinase Complex	Chromatin Nucleus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Regulation Of Protein Localization Stress Granule Assembly Negative Regulation Of Exocytosis Axon Extension Negative Regulation Of Immune Response Autophagosome-lysosome Fusion Regulation Of Synaptic Vesicle Cycle Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19734901 20801718 22959728 24931836 25442119 27455348 29566793 30976013) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)	FEV1 ( 30804560) Lung function (FVC) ( 30804560) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: APP COIL CRX EIF2B2 HMG20A POP7 REL SRPK1 SYN3 TRIM73 VRTN	10 interacting genes: C9orf72 CTBP2 EIF4A3 FAM90A1 POLR3C RAB2B RAB3A RAB3B RAB3C RAB3D
Entrez ID		203228	55237
HPRD ID		12975	16593
Ensembl ID		ENSG00000147894	ENSG00000133980
Uniprot IDs		Q96LT7	Q9H8Y1
PDB IDs		6LT0 6V4U 7MGE 7O2W
Enriched GO Terms of Interacting Partners?			Myosin V Binding Regulation Of Exocytosis GTP-dependent Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Regulation Of Secretion GTPase Activity Synaptic Vesicle GTP Binding Exocytosis Positive Regulation Of Exocytosis Vesicle-mediated Transport Endosome Regulation Of Synaptic Vesicle Cycle Secretion By Cell Regulation Of Transport Hydrolase Activity Vesicle Nucleotide Binding Secretion Protein Transport Postsynapse Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Presynaptic Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Positive Regulation Of Secretion By Cell Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Positive Regulation Of Secretion Positive Regulation Of Transport Sensory Perception Of Touch Positive Regulation Of Type I Interferon Production Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Regulation Of Dense Core Granule Exocytosis Acrosomal Vesicle Antigen Processing And Presentation Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Secretory Granule Zymogen Granule Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Intracellular Protein Localization Clathrin-sculpted Glutamate Transport Vesicle Membrane Regulation Of Regulated Secretory Pathway Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse Regulation Of Type I Interferon Production Synaptic Vesicle Membrane Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Acrosomal Vesicle Exocytosis
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