C9orf72 and CRX

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		C9orf72	CRX
Gene Name		chromosome 9 open reading frame 72	cone-rod homeobox
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Autophagic Vacuole Actin Cytoskeleton Cytoplasmic Vesicle Intercellular Bridge	Nucleus Transcription Factor Complex
	Molecular Function	Protein Binding Rab GTPase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding
	Biological Process	Endocytosis Autophagy	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Visual Perception Circadian Rhythm Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Photoreceptor Cell Differentiation Response To Stimulus Retina Development In Camera-type Eye
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 22959728 19734901 20801718) PCA3 expression level ( 23555189)
Protein-Protein Interactions		6 interactors: APP CRX EIF2B2 NMI REL SRPK1	44 interactors: ABI2 AES ATG12 ATXN7 BANF1 C1orf109 C9orf72 CA8 CCNC CREBBP CSNK1G2-AS1 EIF5A EP300 GCM2 GUCD1 IPO13 KAT2A KIAA0141 KLHL32 LARP4 LONRF1 M1AP MDFI MLLT6 NIP7 NPAS2 NR2E3 NRL OSGIN1 PARK2 PDC PID1 PPP1R16B PRKAB2 PSMB10 QRICH1 RAX2 RBFOX1 ROR2 SFI1 SOX5 STK16 SZT2 UBXN2B
Entrez ID		203228	1406
HPRD ID		12975	03748
Ensembl ID		ENSG00000147894	ENSG00000105392
Uniprot IDs		Q96LT7 Q9NUW0	O43186
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression Defense Response RNA Metabolic Process Positive Regulation Of Photoreceptor Cell Differentiation Response To Stress Synaptic Growth At Neuromuscular Junction Innate Immune Response Collateral Sprouting In Absence Of Injury Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Reproduction Axon Choice Point Recognition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Regulation Of Gene Expression Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Sperm Chromatin Condensation Rhythmic Process Immune Response Positive Regulation Of Interleukin-12 Biosynthetic Process Reproductive Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Processing Inflammatory Response Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Viral Genome Replication Copper Ion Homeostasis Suckling Behavior Neurogenesis Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Rhodopsin Gene Expression N-terminal Peptidyl-lysine Acetylation Regulation Of Rhodopsin Gene Expression Transcription, DNA-templated Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitochondrial Fusion Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Autophagy N-terminal Protein Amino Acid Acetylation Nuclear Envelope Reassembly Cellular Response To Stimulus Response To Stimulus Negative Regulation Of Wnt Signaling Pathway Cellular Metabolic Process Somitogenesis Cellular Nitrogen Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone Deubiquitination Neurological System Process Somite Development Cellular Response To Stress Regulation Of Type I Interferon Production Peptidyl-amino Acid Modification Peptidyl-lysine Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		990a als amyotrophic arg522arg brainstem causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous tardbp val14met	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate photoreceptor pigmentation playing progenitor prolongs remarkably repressing retinal retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Difference) ?		990a als amyotrophic arg522arg brainstem causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous tardbp val14met	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate photoreceptor pigmentation playing progenitor prolongs remarkably repressing retinal retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Intersection) ?