ATP6AP1

Description		ATPase H+ transporting accessory protein 1
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Endomembrane System Membrane Proton-transporting Two-sector ATPase Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase Complex Synapse Extracellular Exosome Bounding Membrane Of Organelle
	Molecular Function	ATPase Activator Activity Protein Binding Small GTPase Binding Transporter Activator Activity
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Cellular PH Osteoclast Development Cellular Response To Increased Oxygen Levels Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Endosome To Plasma Membrane Protein Transport Proton Transmembrane Transport
Pathways		Insulin receptor recycling RHOA GTPase cycle Transferrin endocytosis and recycling Ion channel transport
Drugs		Tiludronic acid
Diseases
GWAS
Novel Interacting Genes		5 novel interacting genes: ABCD1 CETN2 CTAG1B LARP1 NT5E
Interacting Genes		6 interacting genes: ANG ERBB2 HBA1 NR1I2 OGT RHOU
Entrez ID		537
HPRD ID		02184
Ensembl ID		ENSG00000071553
Uniprot IDs		A0A384MQW4 Q15904
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Catabolic Process Sulfur Compound Transmembrane Transporter Activity Positive Regulation Of Lipid Biosynthetic Process Fatty-acyl-CoA Transport Very Long-chain Fatty-acyl-CoA Metabolic Process Organophosphate Ester Transmembrane Transporter Activity Very Long-chain Fatty-acyl-CoA Catabolic Process Amide Transmembrane Transporter Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Nucleobase-containing Compound Transmembrane Transporter Activity Homeostatic Process ABC-type Fatty-acyl-CoA Transporter Activity Catabolic Process Cytosol Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization TRNA-specific Ribonuclease Activity Regulation Of Translation Cytoplasmic Stress Granule Membraneless Organelle Assembly Angiogenin-PRI Complex Negative Regulation Of Catabolic Process Regulation Of Protein Localization Translation Positive Regulation Of Establishment Of Protein Localization XPC Complex RNA Polymerase I Core Binding ERBB3:ERBB2 Complex Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Translation Haptoglobin Binding 5'-deoxynucleotidase Activity Adenosine Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation TOR Signaling Positive Regulation Of Translational Initiation TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity Cellular Response To Rapamycin Regulation Of Translational Initiation Nucleoside Phosphate Catabolic Process Regulation Of Biological Quality Regulation Of Generation Of Precursor Metabolites And Energy Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Import Into Peroxisome Cytoplasmic Translation
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