ATP6AP1 and ANG

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATP6AP1	ANG
Gene Name		ATPase, H+ transporting, lysosomal accessory protein 1	angiogenin, ribonuclease, RNase A family, 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Membrane Endosome Membrane Integral Component Of Membrane Proton-transporting Two-sector ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Vesicular Exosome	Basal Lamina Extracellular Space Nucleus Nucleolus Growth Cone Angiogenin-PRI Complex Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity ATP Binding Rab GTPase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	DNA Binding Actin Binding Endonuclease Activity Ribonuclease Activity Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Proton Transport Transferrin Transport Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Resorption PH Reduction Positive Regulation Of Exocytosis Establishment Of Organelle Localization Transmembrane Transport Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Osteoclast Development	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone Cell Migration Negative Regulation Of Translation Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis
Pathways		Iron uptake and transport Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor
Drugs			Pyrophosphate 2- Pyroglutamic Acid Citric Acid
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ANG HBA1 NR1I2 SYVN1	8 interactors: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8
Entrez ID		537	283
HPRD ID		02184	00105
Ensembl ID		ENSG00000071553	ENSG00000214274
Uniprot IDs		Q15904 Q8NBT4	P03950
PDB IDs			1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36
Enriched GO Terms of Interacting Partners?		Drug Export Diacylglycerol Biosynthetic Process Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Xenobiotic Transport Catabolic Process Regulation Of Phospholipase A2 Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Hydrogen Peroxide Catabolic Process Diacylglycerol Metabolic Process Positive Regulation Of Transferase Activity Exogenous Drug Catabolic Process Drug Catabolic Process RRNA Transcription Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Oocyte Maturation Oxygen Transport Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Activation Of Protein Kinase B Activity	Cardiac Muscle Tissue Development Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Striated Muscle Tissue Development Muscle Tissue Development Actin Filament-based Movement Negative Regulation Of Transport Endothelial Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Epithelial Cell Migration Epithelium Migration Response To Drug Heart Development Cardiac Muscle Cell Differentiation Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Activation Of APC-Cdc20 Complex Activity Postsynaptic Density Assembly Negative Regulation Of Presynaptic Membrane Organization Regulation Of Cell-matrix Adhesion Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Cardiocyte Differentiation Response To Ethanol Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Death Negative Regulation Of Ribosome Biogenesis Central Nervous System Myelin Maintenance Positive Regulation Of Osteoclast Development Ameboidal-type Cell Migration Regulation Of Presynaptic Membrane Organization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Spine Development Microspike Assembly Rhythmic Synaptic Transmission Skeletal Muscle Thin Filament Assembly Activation Of Anaphase-promoting Complex Activity Synapse Maturation Muscle Contraction Response To Nutrient Cardiovascular System Development Striated Muscle Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Intestinal Cholesterol Absorption Male Mating Behavior
Tagcloud ?		abcf2 adprtl1 amy2b arhgap4 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms needle probes renin salt upregulates vasodilatory
Tagcloud (Difference) ?		abcf2 adprtl1 amy2b arhgap4 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms needle probes renin salt upregulates vasodilatory
Tagcloud (Intersection) ?