ATP6AP1 and NR1I2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ATP6AP1	NR1I2
Gene Name		ATPase, H+ transporting, lysosomal accessory protein 1	nuclear receptor subfamily 1, group I, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Membrane Endosome Membrane Integral Component Of Membrane Proton-transporting Two-sector ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Vesicular Exosome	Nucleoplasm
	Molecular Function	Transporter Activity ATP Binding Rab GTPase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Proton Transport Transferrin Transport Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Resorption PH Reduction Positive Regulation Of Exocytosis Establishment Of Organelle Localization Transmembrane Transport Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Osteoclast Development	Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Exogenous Drug Catabolic Process Xenobiotic Transport Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Drug Export
Pathways		Iron uptake and transport Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor
Drugs			Vitamin E Erlotinib Estradiol Ethinyl Estradiol Rifampin Rifaximin Paclitaxel Hyperforin SR12813 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Rilpivirine
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ANG HBA1 NR1I2 SYVN1	27 interactors: ACTN2 ATP6AP1 CHMP1A DYRK2 EIF3I FGR MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBR5
Entrez ID		537	8856
HPRD ID		02184	04346
Ensembl ID		ENSG00000071553	ENSG00000144852
Uniprot IDs		Q15904 Q8NBT4	F1D8P9 O75469
PDB IDs			1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X
Enriched GO Terms of Interacting Partners?		Drug Export Diacylglycerol Biosynthetic Process Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Xenobiotic Transport Catabolic Process Regulation Of Phospholipase A2 Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Hydrogen Peroxide Catabolic Process Diacylglycerol Metabolic Process Positive Regulation Of Transferase Activity Exogenous Drug Catabolic Process Drug Catabolic Process RRNA Transcription Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Oocyte Maturation Oxygen Transport Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Activation Of Protein Kinase B Activity	Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Regulation Of Metabolic Process Cell Communication Cellular Response To Hormone Stimulus Positive Regulation Of Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Signal Transduction Response To Organic Substance Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Stimulus Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Signal Transduction Cell Differentiation Regulation Of Cellular Process Response To Steroid Hormone Negative Regulation Of Cellular Metabolic Process Regulation Of Carbohydrate Metabolic Process Developmental Process Involved In Reproduction Regulation Of Signaling Gland Development Reproductive Structure Development Reproductive System Development In Utero Embryonic Development Mammary Gland Development Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		abcf2 adprtl1 amy2b arhgap4 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl
Tagcloud (Difference) ?		abcf2 adprtl1 amy2b arhgap4 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl
Tagcloud (Intersection) ?