TDO2 and ASMTL

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		TDO2	ASMTL
Description		tryptophan 2,3-dioxygenase	acetylserotonin O-methyltransferase like
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GO Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Protein Binding Oxidoreductase Activity Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity	Protein Binding Methyltransferase Activity O-methyltransferase Activity Transferase Activity Hydrolase Activity DTTP Diphosphatase Activity UTP Diphosphatase Activity Protein Dimerization Activity Nucleoside Triphosphate Diphosphatase Activity
	Biological Process	L-tryptophan Metabolic Process L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine L-tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin	Nucleotide Metabolic Process Methylation
Pathways		Tryptophan catabolism
Drugs
Diseases
GWAS		Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)
Interacting Genes		20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26	10 interacting genes: APP GORASP2 HLA-DRB4 KRT31 KRT34 KRT40 PNMA1 REL TDO2 ZNF655
Entrez ID		6999	8623
HPRD ID		01847	02156
Ensembl ID		ENSG00000151790	ENSG00000169093
Uniprot IDs		P48775	B3KM43 O95671
PDB IDs		4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6UD5 6VBN 7LU7 7UI3 8QV7 8R5Q 8R5R 8VTQ 8VUG 8VZV 8W1H 8W2K 9AT2 9B17 9B1Q 9EZJ	2P5X 6XI4 6XI5
Enriched GO Terms of Interacting Partners?			Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Supramolecular Fiber Organization Structural Molecule Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway L-tryptophan Catabolic Process To Acetyl-CoA Morphogenesis Of An Epithelium Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Epithelial Cell Differentiation Tissue Morphogenesis Tryptophan 2,3-dioxygenase Activity Response To Nitroglycerin Trans-Golgi Network Membrane Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling NF-kappaB Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon L-tryptophan Catabolic Process To Kynurenine Epidermis Development Immune Response Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity
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