CREG1 and RBL1

Number of citations of the paper that reports this interaction (PubMedID 9710587)
75

Data Source:
HPRD (in vitro)

		CREG1	RBL1
Description		cellular repressor of E1A stimulated genes 1	RB transcriptional corepressor like 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Transcription Regulator Complex Cytoplasm Lysosome Endosome Endomembrane System Azurophil Granule Lumen Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Corepressor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endocytosis Autophagy Lysosome Organization Lysosomal Lumen Acidification Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence
Pathways		Neutrophil degranulation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1
Drugs
Diseases
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576)	Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 28957414 32888494)
Interacting Genes		6 interacting genes: CAPN1 IGF2R RB1 RBL1 RBL2 TBP	55 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB1 PLSCR1 PPP1R9B PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4
Entrez ID		8804	5933
HPRD ID		09897	00312
Ensembl ID		ENSG00000143162	ENSG00000080839
Uniprot IDs		O75629	P28749
PDB IDs		1XHN	1H28 4YOO 4YOS 4YOZ 5TUV 7SMC 7SMD 7SME 7SMF
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Extracellular Exosome Regulation Of Catalytic Activity Phosphoprotein Binding Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Promoter-specific Chromatin Binding Enzyme Binding Protein Transport Into Plasma Membrane Raft Regulation Of Phosphorylation Protein Transport Into Membrane Raft Calpain Complex Male Gamete Generation Spermatogenesis Insulin-like Growth Factor Receptor Activity Response To Tetrachloromethane Flavin-dependent Sulfhydryl Oxidase Activity Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization TFIIB-class Transcription Factor Binding Gamete Generation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Mammary Gland Involution Regulation Of Phosphorus Metabolic Process Glial Cell Apoptotic Process Rb-E2F Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Regulation Of Potassium Ion Import NMDA Selective Glutamate Receptor Signaling Pathway Clathrin Coat Thiol Oxidase Activity Negative Regulation Of Myofibroblast Differentiation	Nucleoplasm Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Cellular Response To Stress Mitotic Cell Cycle Phase Transition Response To Stress Cell Cycle Phase Transition Response To Growth Factor Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Binding
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