CREG1 and RBL1

Number of citations of the paper that reports this interaction (PMID 9710587)
9

Data Source:
HPRD (in vitro)

		CREG1	RBL1
Gene Name		cellular repressor of E1A-stimulated genes 1	retinoblastoma-like 1
Image
Gene Ontology Annotations	Cellular Component	Transcription Factor Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Transcription Corepressor Activity Transcription Factor Binding FMN Binding Oxidoreductase Activity	Protein Binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Cell Proliferation Regulation Of Growth Oxidation-reduction Process Negative Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Chromatin Modification Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways			Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CAPN1 IGF2R RB1 RBL1 RBL2 TBP	51 interactors: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 SUV420H2 TAF1 TOP1 USP4
Entrez ID		8804	5933
HPRD ID		09897	00312
Ensembl ID		ENSG00000143162	ENSG00000080839
Uniprot IDs		O75629	P28749
PDB IDs		1XHN	1H28
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Regulation Of Lipid Metabolic Process Viral Process Chromatin Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Chromatin Organization Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Cell Cycle Transcription, DNA-templated Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA-templated Transcription, Initiation RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore Regulation Of Phosphorylation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Cycle Receptor Catabolic Process Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation RNA Metabolic Process Chromatin Silencing At RDNA Positive Regulation Of Chromosome Segregation Regulation Of Phosphorus Metabolic Process Regulation Of Sister Chromatid Cohesion Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hepatocyte Apoptotic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process	Transcription From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Cell Cycle Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Multicellular Organismal Development
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting ctsc enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	accounts adenocarcinoma applicable assist deaths diagnostics effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Intersection) ?		e2f6