CREG1 and ATP1B1

Data Source: HiPPIP (Novel)

		CREG1	ATP1B1
Name		cellular repressor of E1A stimulated genes 1	ATPase Na+/K+ transporting subunit beta 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Transcription Regulator Complex Cytoplasm Lysosome Endosome Endomembrane System Azurophil Granule Lumen Extracellular Exosome	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	Transcription Corepressor Activity	ATPase Activator Activity P-type Sodium:potassium-exchanging Transporter Activity Protein Binding Protein Kinase Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding Transporter Activator Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endocytosis Autophagy Lysosome Organization Lysosomal Lumen Acidification Negative Regulation Of DNA-templated Transcription	Response To Hypoxia Immune System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Metal Ion Transport Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft Innate Immune Response ATP Metabolic Process Protein Stabilization Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Neutrophil degranulation	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		None	Bisacodyl Tegoprazan
GWAS		Asthma ( 31959851 ) Blood protein levels ( 30072576 )	Coronary artery disease ( 29212778 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 25055868 ) Electrocardiographic traits (multivariate) ( 32602732 ) Fuchs's corneal dystrophy ( 28358029 ) Haemorrhoidal disease ( 33888516 ) Keratoconus ( 33649486 ) Mitochondrial DNA levels ( 25240745 ) QT interval ( 19305409 23166209 24952745 29213071 29874175 ) Rosacea symptom severity ( 29771307 )
Novel Interactors		3 novel interactors: ATP1B1 QSOX1 SERPINC1	7 novel interactors: CD84 CREG1 HCRTR1 PRRX1 SERPINC1 THOC1 TM4SF1
Interacting Genes		6 interacting genes: CAPN1 IGF2R RB1 RBL1 RBL2 TBP	23 interacting genes: AGTR1 BACE1 BARD1 BRCA1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HTR2B KMT2B LRIF1 NDRG2 OGT PAXIP1 PSME1 TMEM132D TRIM14 TRMT2A TSC22D2 USP4
Entrez ID		8804	481
HPRD ID		09897	01663
Ensembl ID		ENSG00000143162	ENSG00000143153
Uniprot IDs		O75629	A3KLL5 P05026
PDB IDs		1XHN	7E1Z 7E20 7E21 8D3U 8D3V 8D3W 8D3X 8D3Y 8ZYJ
GO Terms Enriched among Interactors		Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Extracellular Exosome Regulation Of Catalytic Activity Phosphoprotein Binding Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Promoter-specific Chromatin Binding Enzyme Binding Protein Transport Into Plasma Membrane Raft Regulation Of Phosphorylation Protein Transport Into Membrane Raft Calpain Complex Male Gamete Generation Spermatogenesis Insulin-like Growth Factor Receptor Activity Response To Tetrachloromethane Flavin-dependent Sulfhydryl Oxidase Activity Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization TFIIB-class Transcription Factor Binding Gamete Generation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Mammary Gland Involution Regulation Of Phosphorus Metabolic Process Glial Cell Apoptotic Process Rb-E2F Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Regulation Of Potassium Ion Import NMDA Selective Glutamate Receptor Signaling Pathway Clathrin Coat Thiol Oxidase Activity Negative Regulation Of Myofibroblast Differentiation	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Chromatin Organization Angiotensin Type I Receptor Activity Protein K6-linked Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Metabolic Process Regulation Of DNA Damage Checkpoint Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Modification Process Multivesicular Body, Internal Vesicle Lumen Hepatocyte Homeostasis Cardiac Muscle Hypertrophy Muscle Hypertrophy GTP Cyclohydrolase I Activity Negative Regulation Of Protein Glutathionylation Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport Adenosine Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Histone Methyltransferase Complex Nuclear Matrix Golgi-associated Vesicle Lumen C-methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process