CREG1 and IGF2R

Number of citations of the paper that reports this interaction (PubMedID 12934103)
0

Data Source:
HPRD (in vitro)

		CREG1	IGF2R
Description		cellular repressor of E1A stimulated genes 1	insulin like growth factor 2 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Transcription Regulator Complex Cytoplasm Lysosome Endosome Endomembrane System Azurophil Granule Lumen Extracellular Exosome	Golgi Membrane Extracellular Space Nucleus Nuclear Envelope Lumen Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Endomembrane System Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor Receptor Activity Protein Binding Insulin-like Growth Factor Binding D-mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding Retromer Complex Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endocytosis Autophagy Lysosome Organization Lysosomal Lumen Acidification Negative Regulation Of DNA-templated Transcription	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Host-mediated Activation Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Response To Tetrachloromethane
Pathways		Neutrophil degranulation	Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa Mecasermin rinfabate Avalglucosidase alfa
Diseases			Hepatocellular carcinoma
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 26377243) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)
Interacting Genes		6 interacting genes: CAPN1 IGF2R RB1 RBL1 RBL2 TBP	14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3
Entrez ID		8804	3482
HPRD ID		09897	00928
Ensembl ID		ENSG00000143162	ENSG00000197081
Uniprot IDs		O75629	P11717
PDB IDs		1XHN	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32 8AFZ
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Extracellular Exosome Regulation Of Catalytic Activity Phosphoprotein Binding Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Promoter-specific Chromatin Binding Enzyme Binding Protein Transport Into Plasma Membrane Raft Regulation Of Phosphorylation Protein Transport Into Membrane Raft Calpain Complex Male Gamete Generation Spermatogenesis Insulin-like Growth Factor Receptor Activity Response To Tetrachloromethane Flavin-dependent Sulfhydryl Oxidase Activity Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization TFIIB-class Transcription Factor Binding Gamete Generation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Mammary Gland Involution Regulation Of Phosphorus Metabolic Process Glial Cell Apoptotic Process Rb-E2F Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Regulation Of Potassium Ion Import NMDA Selective Glutamate Receptor Signaling Pathway Clathrin Coat Thiol Oxidase Activity Negative Regulation Of Myofibroblast Differentiation	Urokinase Plasminogen Activator Signaling Pathway Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Lysosome Serine-type Endopeptidase Complex Protein Complex Involved In Cell-matrix Adhesion Protein Localization To Cell Periphery Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Ubiquitin Binding Protein Localization To Membrane Phosphatidylinositol Binding Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport To The Plasma Membrane Execution Phase Of Apoptosis Endosome Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Peptidase Activity Trans-Golgi Network Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Protein Catabolic Process Extracellular Region Extracellular Space Cellular Localization Protein Targeting To Vacuole Intracellular Protein Transport Regulation Of Protein Metabolic Process Localization Within Membrane Urokinase Plasminogen Activator Receptor Activity Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Vacuole Protein Transport Regulation Of Protein Maturation Protein Catabolic Process N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Protein Localization To Organelle Aspartic-type Peptidase Activity Cytolytic Granule Lumen Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation
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