CREG1 and SERPINC1

Data Source: HiPPIP (Novel)

		CREG1	SERPINC1
Name		cellular repressor of E1A stimulated genes 1	serpin family C member 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Transcription Regulator Complex Cytoplasm Lysosome Endosome Endomembrane System Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Transcription Corepressor Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endocytosis Autophagy Lysosome Organization Lysosomal Lumen Acidification Negative Regulation Of DNA-templated Transcription	Blood Coagulation Hemostasis Regulation Of Blood Coagulation
Pathways		Neutrophil degranulation	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		None	Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases		None	Inherited thrombophilia
GWAS		Asthma ( 31959851 ) Blood protein levels ( 30072576 )	Experiencing mood swings ( 29500382 ) Heel bone mineral density ( 30598549 )
Novel Interactors		3 novel interactors: ATP1B1 QSOX1 SERPINC1	7 novel interactors: ATP1B1 CHML CREG1 FMO3 MRPS14 PIGC QSOX1
Interacting Genes		6 interacting genes: CAPN1 IGF2R RB1 RBL1 RBL2 TBP	7 interacting genes: F2 HSP90AA1 KLK1 KLK2 KLK6 PLG SDC2
Entrez ID		8804	462
HPRD ID		09897	00122
Ensembl ID		ENSG00000143162	ENSG00000117601
Uniprot IDs		O75629	P01008
PDB IDs		1XHN	1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
GO Terms Enriched among Interactors		Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Extracellular Exosome Regulation Of Catalytic Activity Phosphoprotein Binding Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Promoter-specific Chromatin Binding Enzyme Binding Protein Transport Into Plasma Membrane Raft Regulation Of Phosphorylation Protein Transport Into Membrane Raft Calpain Complex Male Gamete Generation Spermatogenesis Insulin-like Growth Factor Receptor Activity Response To Tetrachloromethane Flavin-dependent Sulfhydryl Oxidase Activity Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization TFIIB-class Transcription Factor Binding Gamete Generation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Mammary Gland Involution Regulation Of Phosphorus Metabolic Process Glial Cell Apoptotic Process Rb-E2F Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Regulation Of Potassium Ion Import NMDA Selective Glutamate Receptor Signaling Pathway Clathrin Coat Thiol Oxidase Activity Negative Regulation Of Myofibroblast Differentiation	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Protein Processing Peptidase Activity Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Space Secretory Granule Regulation Of Fibrinolysis Fibrinolysis Protein Maturation MHC Class II Protein Complex Binding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Biological Quality Biological Process Involved In Interaction With Symbiont Zymogen Activation Protein Metabolic Process Negative Regulation Of Coagulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Region Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Albendazole Monooxygenase Activity CTP Binding DATP Binding Regulation Of Systemic Arterial Blood Pressure Tissue Regeneration Hydrolase Activity Cellular Homeostasis Protein Transport Into Plasma Membrane Raft Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Lumen Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Platelet Alpha Granule Lumen Proteolysis Regulation Of Cardiac Muscle Contraction Striated Muscle Contraction Endopeptidase Activity Rho GDP-dissociation Inhibitor Binding Lysosomal Lumen Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Flavin-dependent Sulfhydryl Oxidase Activity