UNC93A and SLC48A1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		UNC93A	SLC48A1
Name		unc-93 homolog A	solute carrier family 48 member 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Phagolysosome Membrane
	Molecular Function	Protein Binding	Protein Binding Heme Transmembrane Transporter Activity Heme Binding
	Biological Process	None	Phagocytosis Lysosomal Transport Heme Transport Erythrocyte Differentiation Heme Metabolic Process Localization Of Cell Heme Export Heme Export From Vacuole To Cytoplasm
GWAS		Initial alcohol sensitivity ( 30276832 ) Serum metabolite levels ( 33031748 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )	Asthma (adult onset) ( 31036433 ) Bipolar disorder ( 31043756 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 )
Novel Interactors		1 novel interactors: TNFRSF14	None recorded
Interacting Genes		22 interacting genes: ABHD16A AQP6 ATP13A1 CCL4 CD300C CDIPT FCER1G FXYD6-FXYD2 GJA8 GPR101 GPR151 LNPEP PSCA RHAG SLC35E4 SLC39A7 SLC48A1 SYNGR1 TIMMDC1 TMEM14B TMEM237 TMX2	9 interacting genes: APP COMT FXR1 LAMP1 LDAF1 MEOX2 SHANK3 TMEM14B UNC93A
Entrez ID		54346	55652
HPRD ID		12148	07916
Ensembl ID		ENSG00000112494	ENSG00000211584
Uniprot IDs		Q86WB7	Q6P1K1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Carbon Dioxide Transport Transmembrane Transport One-carbon Compound Transport Nitrate Transmembrane Transporter Activity Inorganic Cation Transmembrane Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I IgE Receptor Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Methylammonium Transmembrane Transporter Activity CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Heme Export From Vacuole To Cytoplasm Heme Metabolic Process Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Lymphocyte Migration Porphyrin-containing Compound Metabolic Process PH-gated Chloride Channel Activity Inorganic Ion Transmembrane Transport Nitrate Transmembrane Transport Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Type I Hypersensitivity Plasma Membrane Fc-epsilon Receptor I Complex Methylammonium Transport Methylammonium Transmembrane Transport Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Negative Regulation Of Adaptive Immune Memory Response Alcohol Binding Mitochondrial Membrane Pigment Metabolic Process Tetrapyrrole Metabolic Process Heme Export	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Associative Learning Negative Regulation Of Long-term Synaptic Potentiation Memory Positive Regulation Of Long-term Synaptic Potentiation Learning Response To Catecholamine Dendritic Spine Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Learning Or Memory Amyloid-beta Complex Growth Cone Lamellipodium Cognition Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Norepinephrine Secretion Catechol O-methyltransferase Activity Neuron Projection Regulation Of Synaptic Transmission, Glutamatergic Synapse Acetylcholine Receptor Activator Activity Axon Lipoprotein Particle Positive Regulation Of Protein Import Cellular Response To Phosphate Starvation Guanylate Kinase-associated Protein Clustering PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Dendrite Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Neuromuscular Process Phagolysosome Membrane Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation