UNC93A and CCL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC93A	CCL4
Description		unc-93 homolog A	C-C motif chemokine ligand 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding
	Biological Process		Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Cell Migration Host-mediated Suppression Of Viral Transcription Eosinophil Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Initial alcohol sensitivity ( 30276832) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)	Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		22 interacting genes: ABHD16A AQP6 ATP13A1 CCL4 CD300C CDIPT FCER1G FXYD6-FXYD2 GJA8 GPR101 GPR151 LNPEP PSCA RHAG SLC35E4 SLC39A7 SLC48A1 SYNGR1 TIMMDC1 TMEM14B TMEM237 TMX2	26 interacting genes: ACKR2 ARL13B CCL3 CCR1 CCR3 CCR5 CCR8 CNR2 CXCL8 GJA8 GPR152 GPRC5D MARCHF2 MRM1 SLC10A6 SLC18A1 SLC30A2 SLC30A8 SLC7A1 TAS2R5 TIMMDC1 TMEM14B TMEM179B TMEM31 TMEM86B UNC93A
Entrez ID		54346	6351
HPRD ID		12148	01657
Ensembl ID		ENSG00000112494	ENSG00000275302
Uniprot IDs		Q86WB7	P13236
PDB IDs			1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL
Enriched GO Terms of Interacting Partners?		Membrane Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Carbon Dioxide Transport Transmembrane Transport One-carbon Compound Transport Nitrate Transmembrane Transporter Activity Inorganic Cation Transmembrane Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I IgE Receptor Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Methylammonium Transmembrane Transporter Activity CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Heme Export From Vacuole To Cytoplasm Heme Metabolic Process Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Lymphocyte Migration Porphyrin-containing Compound Metabolic Process PH-gated Chloride Channel Activity Inorganic Ion Transmembrane Transport Nitrate Transmembrane Transport Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Type I Hypersensitivity Plasma Membrane Fc-epsilon Receptor I Complex Methylammonium Transport Methylammonium Transmembrane Transport Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Negative Regulation Of Adaptive Immune Memory Response Alcohol Binding Mitochondrial Membrane Pigment Metabolic Process Tetrapyrrole Metabolic Process Heme Export	Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Chemokine-mediated Signaling Pathway Locomotion G Protein-coupled Receptor Activity Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway Membrane Plasma Membrane Chemokine (C-C Motif) Ligand 5 Binding Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Immune Response Inflammatory Response Response To Cytokine Response To Peptide Zinc:proton Antiporter Activity Cell Motility Leukocyte Migration Cytokine-mediated Signaling Pathway Intracellular Signaling Cassette Cellular Response To Cytokine Stimulus Transport Vesicle Membrane Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Zinc Ion Import Into Organelle Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Monoatomic Cation Transport Defense Response External Side Of Plasma Membrane Sarcoplasmic Reticulum Calcium Ion Transport Dendritic Cell Chemotaxis Metal Ion Transport Transmembrane Transport Response To Interleukin-1 Monoatomic Cation Transmembrane Transporter Activity Import Into Cell Negative Regulation Of Bone Mineralization Positive Regulation Of Leukocyte Chemotaxis Immune System Process Monoatomic Ion Transport Positive Regulation Of Neuroinflammatory Response Secretory Granule Membrane Monocyte Chemotaxis Zinc Ion Transmembrane Transporter Activity Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
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