SERPINA4 and TRIP11

		SERPINA4	TRIP11
Description		serpin family A member 4	thyroid hormone receptor interactor 11
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome	Golgi Membrane Acrosomal Membrane Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Cytoskeleton Cilium Membrane Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Transcription Coactivator Activity Protein Binding Small GTPase Binding
	Biological Process		Ventricular Septum Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Transcription By RNA Polymerase II Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of DNA-templated Transcription Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Bone Development Protein Transmembrane Transport Golgi Ribbon Formation Vesicle Tethering To Golgi
Pathways		Platelet degranulation Developmental Lineage of Pancreatic Acinar Cells	Intraflagellar transport Intra-Golgi traffic Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs		Zinc Copper Zinc acetate
Diseases			Achodrogenesis type IA
GWAS		Blood protein levels ( 30072576) Vaspin levels ( 22907691)	Appendicular lean mass ( 33097823) Body size at age 10 ( 32376654) FEV1 ( 30804560) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391951 31562340 28552196 18391950 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Refractive error ( 32231278) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412)
Interacting Genes		14 interacting genes: CFTR CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1	9 interacting genes: ARNT ATXN1L DSCAM MYBPC2 PSMC5 RB1 SNCA THRA WDR37
Entrez ID		5267	9321
HPRD ID		01004	05143
Ensembl ID		ENSG00000100665	ENSG00000100815
Uniprot IDs		A0A024R6I9 P29622	Q15643
PDB IDs		6F02
Enriched GO Terms of Interacting Partners?			Regulation Of Protein-containing Complex Assembly General Transcription Initiation Factor Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Growth Cone Dendritic Cell Migration Negative Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Inclusion Body TBP-class Protein Binding Locomotory Behavior Phosphoprotein Binding Regulation Of Phosphorus Metabolic Process Nuclear Receptor Activity Social Behavior Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Interleukin-22 Production Regulation Of Actin Filament Organization Skeletal Muscle Cell Differentiation Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Phosphate Metabolic Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Organelle Organization Nuclear Proteasome Complex Striated Muscle Cell Differentiation Erythrocyte Differentiation Transcription By RNA Polymerase II Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Female Courtship Behavior Adult Locomotory Behavior Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Protein Depolymerization Negative Regulation Of DNA-templated Transcription Thyrotropin-releasing Hormone Receptor Binding Negative Regulation Of RNA Biosynthetic Process Chromatin Lock Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity
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