PABPC4 and MKNK1

Data Source: HiPPIP (Novel)

		PABPC4	MKNK1
Name		poly(A) binding protein cytoplasmic 4	MAPK interacting serine/threonine kinase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Regulation Of Translation Protein Phosphorylation Intracellular Signal Transduction
Pathways		None	Spry regulation of FGF signaling
Drugs		None	Fostamatinib
GWAS		Apolipoprotein A1 levels ( 32203549 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) C-reactive protein levels ( 21300955 30388399 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Chronic obstructive pulmonary disease ( 30804561 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Coffee consumption ( 31046077 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27618448 ) HDL cholesterol ( 30275531 24097068 25961943 20686565 ) HDL cholesterol levels ( 32203549 30698716 28334899 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) High density lipoprotein cholesterol levels ( 29615537 ) Mean arterial pressure ( 27618448 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Metabolic syndrome ( 31589552 ) Red cell distribution width ( 27863252 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Walking pace ( 33128006 )	Schizophrenia ( 26198764 ) Triglyceride levels ( 31170924 )
Novel Interactors		10 novel interactors: FOXD3 HCRTR1 LUC7L2 MKNK1 MTF1 NMNAT1 PRKCG S100A8 VPS26B ZNF655	1 novel interactors: PABPC4
Interacting Genes		21 interacting genes: CDC27 CDC42 CEBPA DUX4 EEF1A1 GDF9 HAP1 IL7R MED31 MKRN3 OGT PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 TRIM37 UBC UBXN7 XRN1	26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
Entrez ID		8761	8569
HPRD ID		04557	09468
Ensembl ID		ENSG00000090621	ENSG00000079277
Uniprot IDs		Q13310	A0A499FJN1 A0A499FJS1 A8K341 Q9BUB5
PDB IDs		Not available	2HW6 2Y9Q 5WVD
GO Terms Enriched among Interactors		Nucleus Nucleoplasm	Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Lung Morphogenesis Intracellular Signal Transduction Cellular Response To Nutrient Levels Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Gene Expression Negative Regulation Of Autophagy Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Translation Initiation Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling MAP Kinase Activity Regulation Of Translation Cytoplasm Regulation Of Defense Response Nucleus Intracellular Signaling Cassette Translation Factor Activity, RNA Binding Positive Regulation Of Defense Response Stress-activated MAPK Cascade Interleukin-34-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Translational Initiation Cell Death Stress-activated Protein Kinase Signaling Cascade Response To Growth Factor Regulation Of Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Developmental Process Cytoplasmic Stress Granule Thyroid Gland Development