PABPC4 and NMNAT1

Data Source: HiPPIP (Novel)

		PABPC4	NMNAT1
Name		poly(A) binding protein cytoplasmic 4	nicotinamide nucleotide adenylyltransferase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	Nucleotide Binding Nicotinamide-nucleotide Adenylyltransferase Activity Catalytic Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Purine Nucleotide Metabolic Process Nicotinamide Metabolic Process Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Response To Wounding Pyridine Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development ATP Generation From Poly-ADP-D-ribose
Pathways		None	Nicotinate metabolism
Drugs		None	Nicotinamide Mononucleotide Deamido-Nad+
GWAS		Apolipoprotein A1 levels ( 32203549 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) C-reactive protein levels ( 21300955 30388399 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Chronic obstructive pulmonary disease ( 30804561 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Coffee consumption ( 31046077 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27618448 ) HDL cholesterol ( 30275531 24097068 25961943 20686565 ) HDL cholesterol levels ( 32203549 30698716 28334899 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) High density lipoprotein cholesterol levels ( 29615537 ) Mean arterial pressure ( 27618448 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Metabolic syndrome ( 31589552 ) Red cell distribution width ( 27863252 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Walking pace ( 33128006 )	Resting heart rate ( 27798624 )
Novel Interactors		10 novel interactors: FOXD3 HCRTR1 LUC7L2 MKNK1 MTF1 NMNAT1 PRKCG S100A8 VPS26B ZNF655	1 novel interactors: PABPC4
Interacting Genes		21 interacting genes: CDC27 CDC42 CEBPA DUX4 EEF1A1 GDF9 HAP1 IL7R MED31 MKRN3 OGT PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 TRIM37 UBC UBXN7 XRN1	19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2
Entrez ID		8761	64802
HPRD ID		04557	16369
Ensembl ID		ENSG00000090621	ENSG00000173614
Uniprot IDs		Q13310	B1AN62 Q9HAN9
PDB IDs		Not available	1GZU 1KKU 1KQN 1KQO 1KR2 8QE8
GO Terms Enriched among Interactors		Nucleus Nucleoplasm	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Localization To Nucleus Intracellular Transport Of Virus Host Cell Protein Import Into Nucleus Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Triglyceride Biosynthetic Process Cellular Localization Intracellular Protein Transport Regulation Of Amyloid Precursor Protein Catabolic Process Intracellular Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Negative Regulation Of Triglyceride Metabolic Process Establishment Of Localization In Cell Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Life Cycle Establishment Of Protein Localization Regulation Of Anoikis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Receptor Internalization Intracellular Protein Localization Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Cellular Response To Nerve Growth Factor Stimulus Protein Transport Viral Process Regulation Of Muscle Cell Differentiation