PABPC4 and S100A8

		PABPC4	S100A8
Description		poly(A) binding protein cytoplasmic 4	S100 calcium binding protein A8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Intermediate Filament Cytoskeleton Extracellular Exosome Calprotectin Complex S100A8 Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Peptide Secretion Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Chemotaxis Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Response To Lipopolysaccharide Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs			Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 21300955 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 30275531 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 30698716 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Walking pace ( 33128006)	Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)
Interacting Genes		21 interacting genes: CDC27 CDC42 CEBPA DUX4 EEF1A1 GDF9 HAP1 IL7R MED31 MKRN3 OGT PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 TRIM37 UBC UBXN7 XRN1	22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PCNA PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119
Entrez ID		8761	6279
HPRD ID		04557	00471
Ensembl ID		ENSG00000090621	ENSG00000143546
Uniprot IDs		Q13310	P05109
PDB IDs			1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2 7QUV 8SJB 8SJC
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm	Response To Light Stimulus Molecular Function Activator Activity PCNA-p21 Complex Enzyme Binding Response To Radiation Regulation Of Phosphorus Metabolic Process Regulation Of Growth RAGE Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Microtubule-based Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Nuclear Envelope Lumen Heparan Sulfate Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Phosphate Metabolic Process Stress-induced Premature Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Forebrain Morphogenesis Cytoskeleton-dependent Intracellular Transport Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Growth Regulation Of DNA Biosynthetic Process Replicative Senescence Synapse Maturation Cellular Response To UV Mitotic G1/S Transition Checkpoint Signaling Response To L-glutamate Structural Constituent Of Cytoskeleton Synapse Organization Protein-containing Complex Protein Serine/threonine Kinase Binding Negative Regulation Of Protein Phosphorylation Heart Development Cellular Response To Light Stimulus Circadian Behavior Rhythmic Behavior Response To Amino Acid Regulation Of DNA Replication Negative Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Dentate Gyrus Development Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Synapse Organization Positive Regulation Of Excitatory Postsynaptic Potential Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cytosol Regulation Of Cellular Response To Stress Negative Regulation Of DNA Metabolic Process
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