PABPC4 and RIF1

Number of citations of the paper that reports this interaction (PubMedID 15383276)
0

Data Source:
HPRD (two hybrid)

		PABPC4	RIF1
Description		poly(A) binding protein cytoplasmic 4	replication timing regulatory factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Chromosome, Telomeric Region Chromatin Condensed Chromosome Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Nuclear Membrane Site Of Double-strand Break Spindle Midzone Chromosome, Telomeric Repeat Region
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	Protein Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Repair DNA Damage Response Subtelomeric Heterochromatin Formation Somatic Stem Cell Population Maintenance Telomere Maintenance In Response To DNA Damage Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Isotype Switching Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 21300955 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 30275531 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 30698716 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Walking pace ( 33128006)	Lung cancer ( 23143601) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		21 interacting genes: CDC27 CDC42 CEBPA DUX4 EEF1A1 GDF9 HAP1 IL7R MED31 MKRN3 OGT PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 TRIM37 UBC UBXN7 XRN1	20 interacting genes: BRD7 CEP126 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 LINC00839 NSG2 PABPC4 PIAS4 POT1 PPP1CC SETDB1 SMARCD1 SUMO2 TERF2IP UBC
Entrez ID		8761	55183
HPRD ID		04557	10603
Ensembl ID		ENSG00000090621	ENSG00000080345
Uniprot IDs		Q13310	Q5UIP0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm	Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Shelterin Complex Regulation Of Microtubule-based Movement Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Centrosome Telomere Capping Presynapse RSC-type Complex Protein Tag Activity Protein Phosphatase Binding Regulation Of Chromosome Organization Regulation Of Microtubule-based Process Positive Regulation Of Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization SUMO Transferase Activity PML Body Regulation Of Cellular Response To Stress Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Nucleotide-excision Repair Positive Regulation Of DNA Repair Nuclear Matrix Growth Cone Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Gamma-tubulin Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Chromosome Chromosome, Telomeric Region Kinetochore Regulation Of G0 To G1 Transition Positive Regulation Of Neurotrophin Production Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of ARF Protein Signal Transduction Positive Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization
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