PABPC4 and LUC7L2

Number of citations of the paper that reports this interaction (PubMedID 26344197)
49

Data Source:
BioGRID (affinity chromatography technology, biochemical)

		PABPC4	LUC7L2
Description		poly(A) binding protein cytoplasmic 4	LUC7 like 2, pre-mRNA splicing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	RNA Binding MRNA Binding Protein Binding Enzyme Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	MRNA Splice Site Recognition
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 21300955 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 30275531 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 30698716 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Walking pace ( 33128006)	Diisocyanate-induced asthma ( 25918132) Left ventricular end-diastolic volume (MTAG) ( 33495596) Left ventricular end-systolic volume (MTAG) ( 33495596)
Interacting Genes		21 interacting genes: CDC27 CDC42 CEBPA DUX4 EEF1A1 GDF9 HAP1 IL7R MED31 MKRN3 OGT PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 TRIM37 UBC UBXN7 XRN1	67 interacting genes: AIMP2 ALB ANKHD1 ANTKMT AP2M1 APP APPBP2 ATF7IP ATRX C1orf35 CADPS CDC37 CDK4 CDK5RAP2 CEP126 CHD3 COXFA4L2 DHX8 DZIP1 EXOC1 FXR1 GADD45G GSK3B HAP1 HDHD2 HOXA1 IKBKG ITPRID2 KLHL20 LPL MAN2A2 MAP1LC3B MEOX2 NAP1L5 NASP NAT9 NDEL1 NEDD4 NFYA NKAP NSF NUTF2 OFD1 OGT PDPK1 PEA15 PIK3R3 PRPF38A PTCD3 PTN RHOA SAT1 SETDB1 SNRNP48 SRPK2 SRRM4 SRSF6 SRSF7 SRSF8 SVIL ULK2 UNC119 WASHC3 WEE2-AS1 YWHAG ZCCHC10 ZRSR2
Entrez ID		8761	51631
HPRD ID		04557	17456
Ensembl ID		ENSG00000090621	ENSG00000146963
Uniprot IDs		Q13310	Q9Y383
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm	Protein Binding Negative Regulation Of Long-term Synaptic Potentiation Cytosol RNA Splicing Protein-containing Complex Organization Regulation Of Long-term Synaptic Potentiation Presynapse MRNA Processing Nucleus Cellular Component Assembly Low-density Lipoprotein Particle Mediated Signaling Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Microtubule Cytoskeleton Organization Involved In Mitosis Intracellular Protein Localization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding Positive Regulation Of Protein Localization To Cilium Insulin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein-containing Complex Assembly Microtubule Organizing Center Organization Positive Regulation Of Cilium Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Microtubule Associated Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Spindle Organization Organelle Assembly MRNA Binding MRNA Metabolic Process Positive Regulation Of Organelle Assembly Regulation Of Protein Localization To Cilium Membraneless Organelle Assembly Regulation Of RNA Splicing Establishment Of Vesicle Localization
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