NUDT21 and JMJD1C

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NUDT21	JMJD1C
Gene Name		nudix (nucleoside diphosphate linked moiety X)-type motif 21	jumonji domain containing 1C
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome MRNA Cleavage Factor Complex Paraspeckles	Intracellular Nucleoplasm
	Molecular Function	RNA Binding MRNA Binding Protein Binding Hydrolase Activity AU-rich Element Binding Protein Homodimerization Activity Histone Deacetylase Binding Poly(A) RNA Binding	Protein Binding Metal Ion Binding Thyroid Hormone Receptor Binding Dioxygenase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Processing RNA Splicing Gene Expression MRNA 3'-end Processing Protein Tetramerization	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Chromatin Modification Oxidation-reduction Process
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Androgen levels ( 22936694) Arthritis (juvenile idiopathic) ( 22354554) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Mean platelet volume ( 22139419 19820697 22423221) Platelet aggregation ( 20526338) Platelet counts ( 22139419 23263863) Sex hormone-binding globulin levels ( 22829776) Triglycerides ( 20686565)
Protein-Protein Interactions		51 interactors: A2M ATXN1 CARM1 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G EXOSC6 F13A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIAA1377 KIFAP3 MASP1 MYL6 NEDD4 NGEF NIF3L1 POLR2C PSMF1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 SEMA5B SF3B1 SHC1 SHFM1 SLC44A1 SNCAIP SNRNP70 SRPK1 TCERG1 TLE1 TRA2A TRIM27 WWOX ZBTB48	12 interactors: AR ESR2 GADD45A MT2A NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA THRB TK1
Entrez ID		11051	221037
HPRD ID		05400	05141
Ensembl ID		ENSG00000167005	ENSG00000171988
Uniprot IDs		O43809	Q15652
PDB IDs		2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T	2YPD
Enriched GO Terms of Interacting Partners?		Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Process Cellular Metabolic Process Viral Process Protein K63-linked Ubiquitination RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Polyubiquitination Negative Regulation Of Complement Activation MRNA 3'-end Processing Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Immune System Process Developmental Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Regulation Of Dendrite Development Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Blood Coagulation Macromolecule Biosynthetic Process Hemostasis Protein Oligomerization MRNA Polyadenylation Anatomical Structure Development	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway Response To Steroid Hormone DNA-templated Transcription, Initiation Histone H2A K63-linked Ubiquitination Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Reproductive Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Lipid Negative Regulation Of Cellular Metabolic Process Response To Lipid Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Peroxisome Proliferator Activated Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Prostate Gland Development Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Interstrand Cross-link Repair Single Organism Reproductive Process Developmental Process Involved In Reproduction Protein Tetramerization Negative Regulation Of Gene Expression Histone H2A Ubiquitination Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Epithelial Cell Differentiation Involved In Prostate Gland Development Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of DNA-templated Transcription, Elongation Response To Ionizing Radiation Protein Oligomerization Positive Regulation Of Metabolic Process Response To Stimulus Response To Organic Substance Protein Polyubiquitination Reproductive Structure Development Isotype Switching
Tagcloud ?			catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely nanog newly nucleosome oct4 opposes pluripotency pou5f1 recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Difference) ?			catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely nanog newly nucleosome oct4 opposes pluripotency pou5f1 recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Intersection) ?