NUDT21 and MASP1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NUDT21	MASP1
Description		nudix hydrolase 21	MBL associated serine protease 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Nuclear Body Centriolar Satellite Paraspeckles	Extracellular Region Extracellular Space Nucleoplasm Cytosol Symbiont Cell Surface
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	MRNA Processing Post-transcriptional Regulation Of Gene Expression Cell Differentiation MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Pro-B Cell Differentiation	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Negative Regulation Of Complement Activation Protein Maturation
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)
Interacting Genes		119 interacting genes: A2M ATXN1 CARM1 CDC42 CEBPA CEP126 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G ESR1 EXOSC6 F13A1 FAM90A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIFAP3 KRT75 MASP1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-2 MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200B MIR205 MIR206 MIR20A MIR214 MIR221 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-2 MIR9-2 MIR92A1 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYL6 NEDD4 NGEF NIF3L1 NTAQ1 POLR2C PSMF1 PSPC1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 S100PBP SEM1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP SNRNP70 SPAG8 SRPK1 TCERG1 TEPSIN TLE1 TRA2A TRIM23 TRIM27 WWOX ZNF655	16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1
Entrez ID		11051	5648
HPRD ID		05400	02749
Ensembl ID		ENSG00000167005	ENSG00000127241
Uniprot IDs		O43809	P48740
PDB IDs		2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T 5R4P 5R4Q 5R4R 5R4S 5R4T 5R4U 5R64 5R65 5R66 5R67	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD 7PQO
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Translation Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Blood Vessel Endothelial Cell Migration MRNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration RNA Destabilization Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Regulation Of Macromolecule Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of Developmental Process Negative Regulation Of Sprouting Angiogenesis Regulation Of Metabolic Process Positive Regulation Of Connective Tissue Replacement Regulation Of Translation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Sprouting Angiogenesis Negative Regulation Of Protein Metabolic Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Positive Regulation Of Phagocytosis Response To Stress Regulation Of Phagocytosis Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Regulation Of Immune Response Positive Regulation Of Endocytosis Ribosomal Protein S6 Kinase Activity Cell Killing Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Opsonization Signal Complex Assembly Activation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Cellular Component Organization Regulation Of Apoptotic Cell Clearance Regulation Of Opsonization Serine-type Endopeptidase Complex Regulation Of Innate Immune Response Protein Kinase Binding Complement Activation, GZMK Pathway TOR Signaling Regulation Of Defense Response Humoral Immune Response Regulation Of Cellular Response To Heat Dynactin Binding Regulation Of Cellular Response To Stress Regulation Of Endocytosis Protein Maturation Blood Microparticle Regulation Of Translation In Response To Stress Regulation Of Complement Activation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Signal Transduction Immune Response-activating Signaling Pathway Protein Serine Kinase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Immune Effector Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Response To Bacterium Regulation Of Multicellular Organismal Process
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