PANK4

Gene Name		pantothenate kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm
	Molecular Function	Pantothenate Kinase Activity ATP Binding
	Biological Process	Coenzyme A Biosynthetic Process Phosphorylation
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Coenzyme A biosynthesis Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		2 interactors: CDK20 PEA15
Entrez ID		55229
HPRD ID		07313
Ensembl ID		ENSG00000157881
Uniprot IDs		E9PHT6 Q9NVE7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glucose Import Negative Regulation Of Glucose Transport Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Cycle Response To Morphine Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Glucose Import
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