SLC4A4 and SREBF2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		SLC4A4	SREBF2
Gene Name		solute carrier family 4 (sodium bicarbonate cotransporter), member 4	sterol regulatory element binding transcription factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extracellular Vesicular Exosome	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity	C-8 Sterol Isomerase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding
	Biological Process	Transport Ion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lipid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Storage Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Low-density Lipoprotein Particle Cellular Response To Laminar Fluid Shear Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Regulation Of Cholesterol Homeostasis
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters	Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CA2 CA4 PRKACA SLC4A7 SREBF2	48 interactors: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HDAC3 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LZTR1 MAPK1 MAPK3 MRPS6 NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		8671	6721
HPRD ID		04516	02726
Ensembl ID		ENSG00000080493	ENSG00000198911
Uniprot IDs		A5JJ20 Q9Y6R1	Q12772
PDB IDs			1UKL
Enriched GO Terms of Interacting Partners?		Bicarbonate Transport Cellular Response To Fluid Shear Stress Response To Fluid Shear Stress One-carbon Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Positive Regulation Of Myeloid Leukocyte Differentiation Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of PH Positive Regulation Of Myeloid Cell Differentiation Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Dense Core Granule Biogenesis Anion Transport Regulation Of Myeloid Leukocyte Differentiation Cellular Homeostasis Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-T6 Phosphorylation Positive Regulation Of Dipeptide Transmembrane Transport Small Molecule Metabolic Process Chemical Homeostasis Regulation Of Ion Homeostasis Response To Organic Cyclic Compound Regulation Of Myeloid Cell Differentiation Response To Organic Substance Response To Hormone Cochlear Nucleus Development Positive Regulation Of Cellular PH Reduction Retinal Cell Programmed Cell Death Regulation Of Chloride Transport Epithelium Development Negative Regulation Of Cholesterol Efflux Organ Development Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Laminar Fluid Shear Stress Angiotensin-activated Signaling Pathway Regulation Of Synaptic Transmission Homeostatic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Tight Junction Assembly Negative Regulation Of Cholesterol Transport Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Pons Development	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Signaling Viral Process RNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Protein Sumoylation Cell Communication Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Metabolic Process Biosynthetic Process Cellular Response To Organic Substance Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Cellular Response To Stress Cell Surface Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Rhythmic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dusp12 dysregulation eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined timeless tki transcriptome withdrawal	33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Difference) ?		bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dusp12 dysregulation eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined timeless tki transcriptome withdrawal	33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Intersection) ?