SLC4A4 and CA4

Number of citations: 0 (PubMedID 14567693)
Data Source: HPRD (in vitro, in vivo)

		SLC4A4	CA4
Name		solute carrier family 4 member 4	carbonic anhydrase 4
Structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extracellular Exosome	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Side Of Membrane
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Symporter Activity Identical Protein Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Regulation Of Intracellular PH Transmembrane Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier	Bicarbonate Transport
Pathways		Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) Developmental Lineage of Pancreatic Ductal Cells	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs		None	Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate
Diseases		Proximal renal tubular acidosis (RTA type 2)	Retinitis pigmentosa (RP)
GWAS		Age-related nuclear cataracts ( 24951543 ) Diastolic blood pressure ( 30578418 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) Gut microbiota relative abundance (Faecalibacterium) ( 33208821 ) Heel bone mineral density ( 28869591 30598549 ) Mosquito bite size ( 28199695 ) QT interval ( 24952745 29874175 ) Refractive error ( 32231278 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: XPO1
Interacting Genes		5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2	5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
Entrez ID		8671	762
HPRD ID		04516	00261
Ensembl ID		ENSG00000080493	ENSG00000167434
Uniprot IDs		A5JJ20 Q9Y6R1	P22748
PDB IDs		6CAA	1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6
GO Terms Enriched among Interactors		Carbonate Dehydratase Activity Bicarbonate Transport Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Chemical Homeostasis Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Cellular Response To Fluid Shear Stress Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Cholesterol Metabolic Process Intracellular PH Reduction Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Homeostatic Process Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Steroid Biosynthetic Process Regulation Of Intracellular PH Regulation Of Cellular PH Intracellular Chemical Homeostasis Regulation Of PH Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Cellular Homeostasis Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity C-8 Sterol Isomerase Activity Positive Regulation Of Lipid Metabolic Process Lyase Activity Positive Regulation Of Small Molecule Metabolic Process SREBP-SCAP-Insig Complex Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Sodium:bicarbonate Symporter Activity Regulation Of Lipid Biosynthetic Process Regulation Of Macroautophagy Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport CAMP-dependent Protein Kinase Activity Basolateral Plasma Membrane Channel Activator Activity Positive Regulation Of Cholesterol Storage Auditory Receptor Cell Development Phagosome Acidification Cellular Response To Nutrient Levels CAMP/PKA Signal Transduction	Monoatomic Anion Transmembrane Transporter Activity Solute:inorganic Anion Antiporter Activity Bicarbonate Transport Bicarbonate Transmembrane Transporter Activity Regulation Of Cellular PH Regulation Of Intracellular PH Regulation Of PH Chloride:bicarbonate Antiporter Activity Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Cellular Homeostasis Organic Anion Transport Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Transport Across Blood-brain Barrier Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process PH Elevation Respiratory Burst Involved In Inflammatory Response Homeostatic Process Monoatomic Ion Homeostasis Regulation Of Biological Quality Monoatomic Cation Homeostasis Antiporter Activity Chloride Transmembrane Transport Intracellular Chemical Homeostasis Chloride Transport Inorganic Anion Transmembrane Transport Cellular Response To Triglyceride RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding TORC1 Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Glucose Mediated Signaling Pathway Inorganic Ion Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Response To Triglyceride Sodium:bicarbonate Symporter Activity Regulation Of Glucose Mediated Signaling Pathway Monoatomic Ion Transmembrane Transport Negative Regulation Of Urine Volume Hemoglobin Binding Thioredoxin-dependent Peroxiredoxin Activity Annulate Lamellae SnoRNA Localization R2TP Complex Peroxiredoxin Activity Thioredoxin Peroxidase Activity