SLC4A4 and SLC4A7

Number of citations of the paper that reports this interaction (PubMedID 10600945)
0

Data Source:
HPRD (in vivo)

		SLC4A4	SLC4A7
Description		solute carrier family 4 member 4	solute carrier family 4 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extracellular Exosome	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Stereocilium Cell Projection
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Symporter Activity Identical Protein Binding	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Symporter Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Regulation Of Intracellular PH Transmembrane Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier	Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Auditory Receptor Cell Development Cellular Response To Growth Factor Stimulus Phagosome Acidification Monoatomic Anion Transmembrane Transport
Pathways		Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) Developmental Lineage of Pancreatic Ductal Cells	Bicarbonate transporters RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOF GTPase cycle
Drugs
Diseases		Proximal renal tubular acidosis (RTA type 2)
GWAS		Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 30578418) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 28869591 30598549) Mosquito bite size ( 28199695) QT interval ( 24952745 29874175) Refractive error ( 32231278)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Blood pressure ( 21909110) Breast cancer ( 20453838 21263130 23535729 29059683 19330027) Breast cancer (early onset) ( 24493630) Diastolic blood pressure ( 28739976 27841878 27618452 27618447 25249183 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 25249183) Lymphocyte count ( 32888494) Macular telangiectasia type 2 ( 33654266) Macular thickness ( 30535121) Mean arterial pressure ( 27618448 29403010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 29403010 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 21909115 30578418 28739976 25249183 29403010 27618452 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Urinary potassium excretion ( 31409800) Urinary potassium to creatinine ratio ( 30910378) Uterine fibroids ( 30194396)
Interacting Genes		5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2	8 interacting genes: CFTR CIAO1 DLG4 KRTAP4-5 MTNR1B NHERF1 SLC4A4 YWHAB
Entrez ID		8671	9497
HPRD ID		04516	04521
Ensembl ID		ENSG00000080493	ENSG00000033867
Uniprot IDs		A5JJ20 Q9Y6R1	B5M450 E9PFN4 Q9Y6M7
PDB IDs		6CAA
Enriched GO Terms of Interacting Partners?		Carbonate Dehydratase Activity Bicarbonate Transport Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Chemical Homeostasis Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Cellular Response To Fluid Shear Stress Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Cholesterol Metabolic Process Intracellular PH Reduction Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Homeostatic Process Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Steroid Biosynthetic Process Regulation Of Intracellular PH Regulation Of Cellular PH Intracellular Chemical Homeostasis Regulation Of PH Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Cellular Homeostasis Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity C-8 Sterol Isomerase Activity Positive Regulation Of Lipid Metabolic Process Lyase Activity Positive Regulation Of Small Molecule Metabolic Process SREBP-SCAP-Insig Complex Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Sodium:bicarbonate Symporter Activity Regulation Of Lipid Biosynthetic Process Regulation Of Macroautophagy Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport CAMP-dependent Protein Kinase Activity Basolateral Plasma Membrane Channel Activator Activity Positive Regulation Of Cholesterol Storage Auditory Receptor Cell Development Phagosome Acidification Cellular Response To Nutrient Levels CAMP/PKA Signal Transduction	Chloride Channel Regulator Activity PDZ Domain Binding Regulation Of Membrane Potential Negative Regulation Of Transport Bicarbonate Transport Regulation Of Transport Organic Anion Transport Chemical Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding P2Y1 Nucleotide Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Vascular Process In Circulatory System Circulatory System Process Renal Phosphate Ion Absorption Regulation Of Cellular PH Positive Regulation Of Anion Channel Activity Regulation Of PH Regulation Of Protein Transport Regulation Of Intracellular PH Cell Periphery Regulation Of Behavior Transport Across Blood-brain Barrier Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Intracellular Chemical Homeostasis Regulation Of Establishment Of Protein Localization Positive Regulation Of Monoatomic Anion Transport Beta-1 Adrenergic Receptor Binding Regulation Of Nervous System Process Regulation Of Grooming Behavior Negative Regulation Of Protein Transport Type 3 Metabotropic Glutamate Receptor Binding Inorganic Anion Transport Monoatomic Anion Transmembrane Transport Positive Regulation Of Enamel Mineralization Homeostatic Process Monoatomic Anion Transport Regulation Of System Process Melatonin Receptor Activity Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Sodium:bicarbonate Symporter Activity Cellular Homeostasis Regulation Of Insulin Secretion Positive Regulation Of Tooth Mineralization Transepithelial Water Transport
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