TNKS and SH3BP5

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TNKS	SH3BP5
Gene Name		tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	SH3-domain binding protein 5 (BTK-associated)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Centromeric Region Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Spindle Pole Nuclear Pore Golgi Apparatus Cytosol Nuclear Membrane	Cytoplasm Mitochondrion
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding	Protein Kinase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Mitotic Nuclear Division Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Protein Kinase Activity Signal Transduction Intracellular Signal Transduction
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Alcohol and nictotine co-dependence ( 22488850) Alcohol dependence ( 21956439)
Protein-Protein Interactions		14 interactors: DISC1 FANCD2 FNBP1 LNPEP MCL1 NUMA1 POT1 RNF146 SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 VPS33A	14 interactors: APP BTK CDC5L DISC1 DST EXOC1 MAPK10 MAPK12 MAPK8 MAPK9 SOS1 SPTBN1 SYNE1 TNKS
Entrez ID		8658	9467
HPRD ID		04490	12030
Ensembl ID		ENSG00000173273	ENSG00000131370
Uniprot IDs		E7EQ52 O95271	O60239
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8	4H3B
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomerase Activity Regulation Of DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Organelle Organization Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of Signal Transduction Positive Regulation Of DNA Strand Elongation Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Telomere Maintenance Via Telomere Shortening Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Helicase Activity Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Telomerase Activity	JUN Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Surface Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Fc Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Phosphorylation Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation JNK Cascade Cellular Localization Positive Regulation Of Proteolysis Regulation Of Circadian Rhythm Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Light Stimulus Apoptotic Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Immune Response Defense Response Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Immune Response
Tagcloud ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation	activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via
Tagcloud (Difference) ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation	activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via
Tagcloud (Intersection) ?