SH3BP5 and EXOC1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		SH3BP5	EXOC1
Description		SH3 domain binding protein 5	exocyst complex component 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Membrane Nuclear Body Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Signal Transduction Intracellular Signal Transduction	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Defense Response To Virus Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21956439) Heschl's gyrus morphology ( 25130324) Prudent dietary pattern ( 28644415)	Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Urinary albumin excretion ( 32277301) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: APP BTK CDC5L DISC1 DST EXOC1 IFT20 MAPK10 MAPK12 MAPK8 MAPK9 NAP1L2 SOS1 SPTBN1 SYNE1 TTC3	29 interacting genes: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST ITSN1 KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 NUP54 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SNCA SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIO
Entrez ID		9467	55763
HPRD ID		12030	07615
Ensembl ID		ENSG00000131370	ENSG00000090989
Uniprot IDs		O60239	Q9NV70
PDB IDs		4H3B 6DJL 6IXE 6IXF 6IXG 6IXV
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway JUN Kinase Activity MAP Kinase Activity Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Cell Surface Receptor Signaling Pathway Peptidase Activator Activity Immune Response-regulating Signaling Pathway JNK Cascade Cellular Senescence MAPK Cascade Protein Kinase Activity Positive Regulation Of Cell Differentiation Regulation Of Immune Response Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Response To Light Stimulus Kinase Activity Protein Serine/threonine Kinase Binding Regulation Of Cell Differentiation Signal Transduction Protein Phosphorylation Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Phosphorylation Axon Cytosol Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Transport Along Microtubule Regulation Of Protein-containing Complex Assembly Response To Radiation Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Developmental Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Cellular Response To Oxidative Stress Positive Regulation Of Protein-containing Complex Assembly	Microtubule Binding Microtubule-based Process Cytoskeleton Organelle Organization Phosphatidylinositol 3-kinase Inhibitor Activity Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Cellular Localization Cell Leading Edge Cell Projection Cytoskeleton Organization Positive Regulation Of Cell Size Regulation Of Cytoskeleton Organization Microtubule Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cell Projection Organization Actin Binding Cytoplasmic Vesicle Positive Regulation Of Cellular Component Organization Guanyl-nucleotide Exchange Factor Activity Intracellular Transport Regulation Of Organelle Organization Phagophore Assembly Site Membrane Establishment Of Localization In Cell Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Synapse Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Negative Regulation Of Protein-containing Complex Assembly Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Microtubule-based Process Negative Regulation Of Cellular Component Organization Phagophore Assembly Site Ribophagy Protein-membrane Adaptor Activity Extrinsic Component Of Phagophore Assembly Site Membrane Positive Regulation Of Neuroblast Proliferation Lamellipodium Assembly Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Lamellipodium Assembly Involved In Ameboidal Cell Migration Regulation Of Endocytosis Positive Regulation Of Axon Extension
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