SH3BP5 and MAPK10

Number of citations of the paper that reports this interaction (PMID 12167088)
18

Data Source:
HPRD (in vitro)

		SH3BP5	MAPK10
Gene Name		SH3-domain binding protein 5 (BTK-associated)	mitogen-activated protein kinase 10
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding SH3 Domain Binding	JUN Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Signal Transduction Intracellular Signal Transduction	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction JNK Cascade JUN Phosphorylation Response To Light Stimulus Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Circadian Rhythm Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs			2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine 9-(4-Hydroxyphenyl)-2,7-Phenanthroline Phosphoaminophosphonic Acid-Adenylate Ester N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine N-{2\'-[(4-FLUOROPHENYL)AMINO]-4,4\'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide 1-(3-BROMOPHENYL)-7-CHLORO-6-METHOXY-3,4-DIHYDROISOQUINOLINE
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850) Alcohol dependence ( 21956439)	Liver enzyme levels (alanine transaminase) ( 22001757)
Protein-Protein Interactions		14 interactors: APP BTK CDC5L DISC1 DST EXOC1 MAPK10 MAPK12 MAPK8 MAPK9 SOS1 SPTBN1 SYNE1 TNKS	34 interactors: APP ARRB1 ARRB2 ATF2 BCL2L11 CDK5 CDKN1B CDKN2A CDKN2C CEP290 CREBBP DUSP10 DUSP16 ELK1 GTF3C1 HAX1 HDAC9 HNRNPK JUN KIF26A LDHA MAP2K4 MAPK8IP2 MAPK8IP3 MAPKBP1 MCL1 PKMYT1 PLIN2 RELA SH3BP5 STMN2 TNIP1 TP53 UNC119
Entrez ID		9467	5602
HPRD ID		12030	04207
Ensembl ID		ENSG00000131370	ENSG00000109339
Uniprot IDs		O60239	A8MWW6 P53779 Q499Y8
PDB IDs		4H3B	1JNK 1PMN 1PMQ 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N 3KVX 3OXI 3OY1 3PTG 3RTP 3TTI 3TTJ 3V6R 3V6S 4H36 4H39 4H3B
Enriched GO Terms of Interacting Partners?		JUN Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Surface Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Fc Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Phosphorylation Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation JNK Cascade Cellular Localization Positive Regulation Of Proteolysis Regulation Of Circadian Rhythm Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Light Stimulus Apoptotic Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Immune Response Defense Response Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Immune Response	Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Neuron Death Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Neuron Apoptotic Process Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Regulation Of Signal Transduction Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Apoptotic Mitochondrial Changes Cell Communication MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Innate Immune Response Cellular Response To Stimulus Regulation Of Signaling Apoptotic Process Regulation Of Metabolic Process Response To Stimulus Negative Regulation Of Catalytic Activity Cellular Response To Stress Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cell Death Death Positive Regulation Of Transcription, DNA-templated Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Developmental Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway
Tagcloud ?		activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via	acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mylk oxphos pak3 pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Difference) ?		activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via	acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mylk oxphos pak3 pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Intersection) ?