OASL and THRA

Number of citations of the paper that reports this interaction (PMID 7776974)
105

Data Source:
HPRD (two hybrid)

		OASL	THRA
Gene Name		2-5-oligoadenylate synthetase-like	thyroid hormone receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Cytosol
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity DNA Binding Double-stranded RNA Binding ATP Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding
	Biological Process	Metabolic Process Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS		C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) N-glycan levels ( 21203500)	White blood cell count ( 21738480)
Protein-Protein Interactions		3 interactors: MBD1 SEZ6L2 THRA	56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3
Entrez ID		8638	7067
HPRD ID		04473	07185
Ensembl ID		ENSG00000135114	ENSG00000126351
Uniprot IDs		Q15646	P10827 Q6FH41
PDB IDs		1WH3	1NAV 2H77 2H79 3HZF 3ILZ 3JZB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Female Receptivity Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Female Courtship Behavior Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Female Receptivity Female Mating Behavior Type I Pneumocyte Differentiation Transcription From RNA Polymerase II Promoter Cytoplasmic Sequestering Of Transcription Factor Cytoplasmic Sequestering Of Protein Cartilage Condensation Regulation Of DNA-templated Transcription, Initiation Thyroid Gland Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Myotube Differentiation Mating Behavior Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription Factor Import Into Nucleus Mating Response To Cold Regulation Of Lipid Catabolic Process Regulation Of Myotube Differentiation Lung Epithelial Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cellular Metabolic Process Regulation Of Striated Muscle Cell Differentiation Erythrocyte Differentiation Steroid Hormone Mediated Signaling Pathway Erythrocyte Homeostasis Transcription, DNA-templated Negative Regulation Of Intracellular Transport RNA Biosynthetic Process Negative Regulation Of Protein Complex Assembly Myeloid Cell Homeostasis Hormone-mediated Signaling Pathway Maintenance Of Protein Location In Cell	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development
Tagcloud ?		4a abrogate adaptor altogether antiviral argue cardif ccl5 cleaving compromised counteracts cxcl10 cxcl11 cxcl9 ectopically evasion hcv hepatocytes ifnbeta il28a il29 impairing innate irf3 isg15 isg56 isgs ns3 polyprotein	accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate
Tagcloud (Difference) ?		4a abrogate adaptor altogether antiviral argue cardif ccl5 cleaving compromised counteracts cxcl10 cxcl11 cxcl9 ectopically evasion hcv hepatocytes ifnbeta il28a il29 impairing innate irf3 isg15 isg56 isgs ns3 polyprotein	accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate
Tagcloud (Intersection) ?