OASL and THRA

Number of citations of the paper that reports this interaction (PubMedID 7776974)
0

Data Source:
HPRD (two hybrid)

		OASL	THRA
Description		2'-5'-oligoadenylate synthetase like	thyroid hormone receptor alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding Nucleotidyltransferase Activity Nuclear Thyroid Hormone Receptor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Thyroid Hormone Binding General Transcription Initiation Factor Binding
	Biological Process	Immune System Process Response To Virus Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Defense Response To Other Organism Antiviral Innate Immune Response Positive Regulation Of RIG-I Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Receptor Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription Initiation
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) C-reactive protein ( 22939635) C-reactive protein levels ( 24763700 30388399) Cardiovascular disease risk factors ( 21943158) Hematocrit ( 32888494) Hemoglobin ( 32888494) N-glycan levels ( 21203500 21908519) Serum metabolite levels ( 23093944) Type 2 diabetes ( 30054458)	Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)
Interacting Genes		4 interacting genes: FILNC1 MBD1 SEZ6L2 THRA	68 interacting genes: AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3
Entrez ID		8638	7067
HPRD ID		04473	07185
Ensembl ID		ENSG00000135114	ENSG00000126351
Uniprot IDs		A0A7P0T9H8 Q15646	P10827 Q6FH41
PDB IDs		1WH3 4XQ7	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX 7QDT 8RQO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Thyroid Hormone Receptor Signaling Pathway Female Courtship Behavior Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Female Receptivity Double-stranded Methylated DNA Binding Unmethylated CpG Binding Transcription By RNA Polymerase II Regulation Of Female Receptivity Regulation Of Thyroid Hormone Receptor Signaling Pathway Type I Pneumocyte Differentiation Female Mating Behavior Negative Regulation Of DNA-templated Transcription Initiation Thyroid Hormone Binding Negative Regulation Of Transcription Initiation By RNA Polymerase II Cerebellar Purkinje Cell Layer Development General Transcription Initiation Factor Binding DNA-templated Transcription Synapse Maturation Cell Aggregation Cartilage Condensation Mating Behavior Retinoic Acid Receptor Signaling Pathway Methyl-CpG Binding Lung Epithelial Cell Differentiation TBP-class Protein Binding Lung Cell Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Reproductive Behavior DNA Methylation-dependent Constitutive Heterochromatin Formation Response To Cold	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Nuclear Receptor Binding Regulation Of Primary Metabolic Process Nuclear Retinoic Acid Receptor Binding Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Estrogen Receptor Binding Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Chromatin Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway DNA-templated Transcription Transcription Coactivator Activity Intracellular Signal Transduction Transcription Coregulator Activity Transcription Regulator Complex
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