OASL and SEZ6L2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		OASL	SEZ6L2
Gene Name		2-5-oligoadenylate synthetase-like	seizure related 6 homolog (mouse)-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity DNA Binding Double-stranded RNA Binding ATP Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Metabolic Process Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) N-glycan levels ( 21203500)	Anthropometric traits ( 19260139) Response to taxane treatment (placlitaxel) ( 23006423) Systemic lupus erythematosus ( 23273568)
Protein-Protein Interactions		3 interactors: MBD1 SEZ6L2 THRA	5 interactors: ETV5 FOXA1 OASL TK1 UNG
Entrez ID		8638	26470
HPRD ID		04473	06686
Ensembl ID		ENSG00000135114	ENSG00000174938
Uniprot IDs		Q15646	B7Z5L4 Q6UXD5
PDB IDs		1WH3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Female Receptivity Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Female Courtship Behavior Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Female Receptivity Female Mating Behavior Type I Pneumocyte Differentiation Transcription From RNA Polymerase II Promoter Cytoplasmic Sequestering Of Transcription Factor Cytoplasmic Sequestering Of Protein Cartilage Condensation Regulation Of DNA-templated Transcription, Initiation Thyroid Gland Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Myotube Differentiation Mating Behavior Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription Factor Import Into Nucleus Mating Response To Cold Regulation Of Lipid Catabolic Process Regulation Of Myotube Differentiation Lung Epithelial Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cellular Metabolic Process Regulation Of Striated Muscle Cell Differentiation Erythrocyte Differentiation Steroid Hormone Mediated Signaling Pathway Erythrocyte Homeostasis Transcription, DNA-templated Negative Regulation Of Intracellular Transport RNA Biosynthetic Process Negative Regulation Of Protein Complex Assembly Myeloid Cell Homeostasis Hormone-mediated Signaling Pathway Maintenance Of Protein Location In Cell	Fetal Process Involved In Parturition Skeletal Muscle Cell Proliferation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Prostate Gland Stromal Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Depyrimidination Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Cortisol Thymidine Metabolic Process Epithelial Cell Maturation Involved In Prostate Gland Development Single Organism Reproductive Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Base-excision Repair, AP Site Formation Deoxyribonucleoside Monophosphate Biosynthetic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Pyrimidine Deoxyribonucleotide Catabolic Process Reproductive Process Positive Regulation Of Neuron Differentiation Epithelial-mesenchymal Cell Signaling Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Neurogenesis Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribose Phosphate Catabolic Process Parturition Epithelial Cell Differentiation Involved In Prostate Gland Development Response To Steroid Hormone System Development Negative Regulation Of Epithelial To Mesenchymal Transition Gland Development Positive Regulation Of Cell Development Epithelial Cell Maturation Neuromuscular Synaptic Transmission Response To Copper Ion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Stimulus Regulation Of Neuron Differentiation Nucleotide Metabolic Process Postsynaptic Membrane Organization Nucleobase-containing Compound Metabolic Process Deoxyribonucleotide Catabolic Process Multicellular Organismal Development Neuron Fate Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		4a abrogate adaptor altogether antiviral argue cardif ccl5 cleaving compromised counteracts cxcl10 cxcl11 cxcl9 ectopically evasion hcv hepatocytes ifnbeta il28a il29 impairing innate irf3 isg15 isg56 isgs ns3 polyprotein
Tagcloud (Difference) ?		4a abrogate adaptor altogether antiviral argue cardif ccl5 cleaving compromised counteracts cxcl10 cxcl11 cxcl9 ectopically evasion hcv hepatocytes ifnbeta il28a il29 impairing innate irf3 isg15 isg56 isgs ns3 polyprotein
Tagcloud (Intersection) ?