EIF4EBP3 and EIF4E2

Number of citations: 0 (PubMedID 16189514)
Data Source: HPRD (two hybrid)

		EIF4EBP3	EIF4E2
Name		eukaryotic translation initiation factor 4E binding protein 3	eukaryotic translation initiation factor 4E family member 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Eukaryotic Translation Initiation Factor 4F Complex	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding
	Biological Process	Regulation Of Translation Negative Regulation Of Translation Negative Regulation Of Translational Initiation	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome
Pathways		None	ISG15 antiviral mechanism
GWAS		Metabolite levels ( 23823483 ) Serum immune biomarker levels ( 32066700 )	Height ( 25282103 ) Non-small cell lung cancer (survival) ( 21079520 ) Refractive error ( 32231278 )
Novel Interactors		1 novel interactors: BBS5	7 novel interactors: CAB39 CCL24 MVK PDE4DIP SAG SP140 TGFBRAP1
Interacting Genes		2 interacting genes: EIF4E EIF4E2	46 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9
Entrez ID		8637	9470
HPRD ID		09149	05798
Ensembl ID		ENSG00000243056	ENSG00000135930
Uniprot IDs		O60516	A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1
PDB IDs		Not available	2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
GO Terms Enriched among Interactors		MRNA Cap Binding RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Translation Initiation Factor Activity Translational Initiation P-body Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Translation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Translation BBSome Regulation Of Translation Chromatoid Body Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Negative Regulation Of Type I Interferon-mediated Signaling Pathway Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Melanosome Transport Pigment Granule Localization Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Rescue Of Stalled Ribosome	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium