EIF4E2 and SAG

		EIF4E2	SAG
Description		eukaryotic translation initiation factor 4E family member 2	S-antigen visual arrestin
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol Membrane Cell Projection
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding	G Protein-coupled Receptor Binding Opsin Binding Protein Phosphatase Inhibitor Activity Protein Binding Spectrin Binding Phosphoprotein Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome	G Protein-coupled Receptor Internalization Signal Transduction Cell Surface Receptor Signaling Pathway Sensory Perception G Protein-coupled Opsin Signaling Pathway
Pathways		ISG15 antiviral mechanism	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)	Calcium levels ( 20705733) Crohn's disease ( 22412388) Estimated glomerular filtration rate ( 31152163) Mild obesity-related type 2 diabetes ( 34737425)
Interacting Genes		46 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9	4 interacting genes: ADRA1B CHRM2 CLK3 RHO
Entrez ID		9470	6295
HPRD ID		05798	01625
Ensembl ID		ENSG00000135930	ENSG00000130561
Uniprot IDs		A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	P10523
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium	Alpha1-adrenergic Receptor Activity Regulation Of Heart Contraction Regulation Of Muscle Contraction G Protein-coupled Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuron-glial Cell Signaling G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway Rod Bipolar Cell Differentiation Photoreceptor Inner Segment Membrane 11-cis Retinal Binding Sperm Head Plasma Membrane Thermotaxis Absorption Of Visible Light MRNA Cap Binding Adrenergic Receptor Activity Regulation Of Blood Circulation Regulation Of Muscle System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Arrestin Family Protein Binding Retinal Bipolar Neuron Differentiation Photoreceptor Activity Podosome Assembly Rod Photoreceptor Outer Segment Cholinergic Synapse Photoreceptor Outer Segment Membrane G Protein-coupled Photoreceptor Activity Phototransduction, Visible Light RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Golgi-associated Vesicle Membrane Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Light Intensity Glutamatergic Neuron Differentiation G Protein-coupled Acetylcholine Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Photoreceptor Disc Membrane Translation Factor Activity, RNA Binding Adrenergic Receptor Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Detection Of Temperature Stimulus Detection Of Visible Light Protein Serine/threonine/tyrosine Kinase Activity
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