EIF4E2 and CAB39

		EIF4E2	CAB39
Description		eukaryotic translation initiation factor 4E family member 2	calcium binding protein 39
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GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Extracellular Region Cytoplasm Cytosol Z Disc Protein-containing Complex Secretory Granule Lumen Extracellular Exosome Serine/threonine Protein Kinase Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding	Protein Binding Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Protein Serine/threonine Kinase Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome	Signal Transduction Response To Activity Intracellular Signal Transduction Cellular Hypotonic Response Response To Thyroid Hormone Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways		ISG15 antiviral mechanism	Energy dependent regulation of mTOR by LKB1-AMPK Neutrophil degranulation
Drugs
Diseases
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)
Interacting Genes		46 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9	13 interacting genes: CEBPA CEP44 GOLGA2 IPO5 MCCD1 MED7 PRKAA1 RSL1D1 SHMT2 STK11 STK24 STRADA STRADB
Entrez ID		9470	51719
HPRD ID		05798	10091
Ensembl ID		ENSG00000135930	ENSG00000135932
Uniprot IDs		A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	Q9Y376
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN	1UPK 1UPL 2WTK 3GNI 4FZA 4FZD 4FZF 4NZW 4O27 8VSU
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium	Organelle Disassembly Serine/threonine Protein Kinase Complex Regulation Of Protein Metabolic Process Intracellular Protein-containing Complex Activation Of Protein Kinase Activity Negative Regulation Of Translational Initiation Negative Regulation Of Hepatocyte Apoptotic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Protein Kinase Activity G1 To G0 Transition Regulation Of Translational Initiation Macromolecule Metabolic Process Cadherin Binding Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Protein Phosphorylation Positive Regulation Of Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Phosphorylation Regulation Of Protein Localization To Nucleus Protein Export From Nucleus Regulation Of Translation Rescue Of Stalled Ribosome Intracellular Signal Transduction Negative Regulation Of Translation Protein Kinase Activator Activity Carbohydrate Homeostasis Macrophage Differentiation Glucose Homeostasis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Multicellular Organismal-level Homeostasis Centrosome Cycle Negative Regulation Of Glucosylceramide Biosynthetic Process L-allo-threonine Aldolase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Ribosome Disassembly Negative Regulation Of Immune Response Response To Ketone Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Negative Regulation Of Immune System Process Regulation Of Protein Kinase Activity Regulation Of Immune Response
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