EIF4E2 and CCL24

		EIF4E2	CCL24
Description		eukaryotic translation initiation factor 4E family member 2	C-C motif chemokine ligand 24
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GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Extracellular Region Extracellular Space
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Eosinophil Migration
Pathways		ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)	CCL24 levels ( 25147954) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sarcoidosis ( 32826979) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		46 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9	6 interacting genes: CCL13 CCL21 CCL5 CCR3 CXCL11 XCL1
Entrez ID		9470	6369
HPRD ID		05798	03931
Ensembl ID		ENSG00000135930	ENSG00000106178
Uniprot IDs		A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	O00175
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN	1EIG 1EIH
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium	Chemokine-mediated Signaling Pathway Chemokine Activity Cytokine-mediated Signaling Pathway Cell Chemotaxis CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Leukocyte Chemotaxis Antimicrobial Humoral Response Chemokine Receptor Binding Cytokine Activity Inflammatory Response Granulocyte Chemotaxis Positive Regulation Of T Cell Chemotaxis Leukocyte Migration Regulation Of T Cell Chemotaxis Humoral Immune Response Granulocyte Migration Positive Regulation Of Lymphocyte Chemotaxis Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration Regulation Of Lymphocyte Chemotaxis Killing Of Cells Of Another Organism Myeloid Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of T Cell Migration Cell Migration Positive Regulation Of Lymphocyte Migration Cell Killing Regulation Of T Cell Migration Cell Motility Regulation Of Granulocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Cell Surface Receptor Signaling Pathway Immune Response Cell-cell Signaling Regulation Of Lymphocyte Migration Signaling Cell Communication Defense Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Transport Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Cellular Response To Cytokine Stimulus
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