EIF4E2 and TGFBRAP1

		EIF4E2	TGFBRAP1
Description		eukaryotic translation initiation factor 4E family member 2	transforming growth factor beta receptor associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Cytoplasm Endosome Early Endosome Endomembrane System Membrane CORVET Complex
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome	Regulation Of DNA-templated Transcription Intracellular Protein Transport Autophagy Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly
Pathways		ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)	AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Gut microbiota relative abundance (Coprococcus) ( 33208821) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011) Walking pace ( 33128006)
Interacting Genes		46 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9	9 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A SMAD2 SMAD4 TGFBR1 TGFBR2
Entrez ID		9470	9392
HPRD ID		05798	06948
Ensembl ID		ENSG00000135930	ENSG00000135966
Uniprot IDs		A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	Q8WUH2
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium	Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Roof Of Mouth Development Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Signaling Pathway In Utero Embryonic Development Chordate Embryonic Development Positive Regulation Of SMAD Protein Signal Transduction Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Cellular Response To Growth Factor Stimulus I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Endocardial Cushion Morphogenesis Positive Regulation Of Developmental Process Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cell Differentiation Heart Development Regionalization Negative Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Ossification Trophoblast Cell Migration Ventricular Septum Morphogenesis Positive Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity Gastrulation Anterior/posterior Pattern Specification Mesoderm Development Protein Serine/threonine Kinase Activity Pattern Specification Process Positive Regulation Of Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Tissue Morphogenesis Artery Morphogenesis Secondary Palate Development Embryonic Morphogenesis Receptor Complex Anatomical Structure Formation Involved In Morphogenesis Response To Transforming Growth Factor Beta Cardiac Septum Morphogenesis
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