EIF4E2 and SP140

		EIF4E2	SP140
Description		eukaryotic translation initiation factor 4E family member 2	SP140 nuclear body protein
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GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Fibrillar Center Nucleus Nucleolus Cytoplasm Mitochondrion PML Body
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome	Regulation Of Transcription By RNA Polymerase II Defense Response
Pathways		ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)	Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 23770605 24292274 18758461 28165464) Crohn's disease ( 21102463 23128233 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of granulocytes ( 27863252) Night sleep phenotypes ( 27126917) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		46 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9	2 interacting genes: NFE2L2 SIRT2
Entrez ID		9470	11262
HPRD ID		05798	09780
Ensembl ID		ENSG00000135930	ENSG00000079263
Uniprot IDs		A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	B4DVW8 Q0VGE4 Q13342 Q8IWJ1
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN	2MD7 2MD8 6G8R 8J70 8J71
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium	Response To Caloric Restriction Cellular Response To Decreased Oxygen Levels Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Oxygen Levels Cellular Response To Hypoxia Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Glutathione Biosynthetic Process Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Aflatoxin Catabolic Process Histone H4K16 Deacetylase Activity, NAD-dependent Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction NAD-dependent Protein Depalmitoylase Activity Tubulin Deacetylase Activity NAD-dependent Protein Demyristoylase Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Tubulin Deacetylation Positive Regulation Of Oocyte Maturation Peptidyl-lysine Deacetylation Proteasomal Ubiquitin-independent Protein Catabolic Process Toxin Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Protein Metabolic Process MRNA Cap Binding Lateral Loop Negative Regulation Of Peptidyl-threonine Phosphorylation Cellular Response To Chemical Stress Response To Hypoxia Histone Deacetylase Activity, NAD-dependent Negative Regulation Of Satellite Cell Differentiation Ubiquitin Protein Ligase Binding Cellular Response To Methionine Response To Decreased Oxygen Levels Regulation Of Removal Of Superoxide Radicals Regulation Of Oligodendrocyte Progenitor Proliferation Response To Methionine Response To Oxygen Levels RDNA Heterochromatin Formation Negative Regulation Of Skeletal Muscle Cell Differentiation NAD-dependent Protein Lysine Deacetylase Activity Aflatoxin Metabolic Process Regulation Of Protein Catabolic Process Response To Oxidative Stress Skeletal Muscle Satellite Cell Differentiation
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