PTGER3 and INCA1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PTGER3	INCA1
Gene Name		prostaglandin E receptor 3 (subtype EP3)	inhibitor of CDK, cyclin A1 interacting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm
	Molecular Function	Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Prostaglandin E Receptor Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process	Fever Generation Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Death Bicarbonate Transport Intracellular Receptor Signaling Pathway Positive Regulation Of Fever Generation Response To Lipopolysaccharide Positive Regulation Of Urine Volume	Negative Regulation Of Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		23 interactors: ADAMTSL4 CCDC33 CDA EFEMP2 INCA1 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MEOX2 MGAT5B MKLN1 NOTCH2NL PTGER1 REL RGS17 RGS20 SPRY2 TCF4 TRIM42	33 interactors: ARMC7 CABP5 CCNA1 CDC23 CDK2 CDKN2D CHCHD2 COL8A1 CTNNBIP1 DMRT3 EPHB6 FAM103A1 FHL2 FMR1 GRB2 HAUS1 NEK6 OSGIN1 PATE1 PTGER3 RBPMS SAP18 SCNM1 SEC14L4 SPG21 STAMBPL1 STK16 TRIP6 UBE2D4 UBXN2B VPS28 ZMYND19 ZNF205-AS1
Entrez ID		5733	388324
HPRD ID		08906	17150
Ensembl ID		ENSG00000050628	ENSG00000196388
Uniprot IDs		B1AK19 O00325 P43115	Q0VD86
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway	Mitotic Nuclear Division Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein K11-linked Ubiquitination G1/S Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Recruitment Of MRNA Capping Enzyme To RNA Polymerase II Holoenzyme Complex Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Process Cell Cycle Checkpoint Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Modification-dependent Protein Catabolic Process Nuclear Envelope Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Acute Inflammatory Response Atrial Cardiac Muscle Cell Development Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Cycle Regulation Of Cell Cycle Cellular Protein Catabolic Process Gene Expression Spindle Assembly RNA Processing Positive Regulation Of DNA-dependent DNA Replication Initiation Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Fever Generation
Tagcloud ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptgir ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1	accompanied arrest bax bcl2 birc5 ccna1 cdk2 cdkn1a deregulation entering g2 lats2 microrna mir modification namely nasopharyngeal nine npc phenotypes possibly precursor preliminary progression suppressing tp53 transfected tw01 words
Tagcloud (Difference) ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptgir ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1	accompanied arrest bax bcl2 birc5 ccna1 cdk2 cdkn1a deregulation entering g2 lats2 microrna mir modification namely nasopharyngeal nine npc phenotypes possibly precursor preliminary progression suppressing tp53 transfected tw01 words
Tagcloud (Intersection) ?