TNFSF9 and TNFRSF9

Number of citations of the paper that reports this interaction (PMID 8088337)
28

Data Source:
HPRD (in vivo)

		TNFSF9	TNFRSF9
Gene Name		tumor necrosis factor (ligand) superfamily, member 9	tumor necrosis factor receptor superfamily, member 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane	Extracellular Space Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Receptor Activity Cytokine Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Cell Proliferation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Activated T Cell Proliferation Myeloid Dendritic Cell Differentiation Positive Regulation Of Cytotoxic T Cell Differentiation	Apoptotic Process Negative Regulation Of Cell Proliferation Protein Homotrimerization Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Interleukin-12 Secretion
Pathways
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		3 interactors: TNFRSF9 TRAF1 TRAF2	6 interactors: LRR1 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3
Entrez ID		8744	3604
HPRD ID		05861	03767
Ensembl ID		ENSG00000125657
Uniprot IDs		P41273	Q07011
PDB IDs		2X29
Enriched GO Terms of Interacting Partners?		Protein Homotrimerization Protein Trimerization Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Programmed Cell Death Protein Complex Assembly Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Interleukin-12 Secretion Protein Homooligomerization Regulation Of Interleukin-12 Secretion Negative Regulation Of Interleukin-10 Secretion Cellular Component Assembly Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Secretion Protein Oligomerization Positive Regulation Of Protein Homodimerization Activity Cellular Response To Nitric Oxide Regulation Of Cytokine Production Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Negative Regulation Of Interleukin-10 Production Regulation Of Protein Transport Regulation Of Secretion Positive Regulation Of T Cell Cytokine Production Regulation Of Protein Homodimerization Activity Regulation Of Establishment Of Protein Localization Regulation Of Interleukin-10 Secretion Cellular Response To Reactive Nitrogen Species Negative Regulation Of Interleukin-12 Production Regulation Of T Cell Cytokine Production Regulation Of Protein Localization Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cytokine Secretion NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Protein Autoubiquitination Programmed Necrotic Cell Death Regulation Of Cellular Localization Necrotic Cell Death Positive Regulation Of Cytokine Production Involved In Immune Response I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway	Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Cell Death Cell Death Death Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Regulation Of Immunoglobulin Secretion Regulation Of Cytokine Production Positive Regulation Of Immune System Process Positive Regulation Of Cell Activation Apoptotic Process Regulation Of Lymphocyte Activation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Protein Ubiquitination Cellular Response To Cytokine Stimulus Toll-like Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Cytokine Positive Regulation Of Cytotoxic T Cell Differentiation Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cytokine Production Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Immunoglobulin Secretion Regulation Of T Cell Activation Positive Regulation Of Protein Homodimerization Activity Signal Transduction
Tagcloud ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome serpini1 silac silico sostdc1 spectrometer tumorigenic velos zg16b	ab block bmp brc differ downregulated estradiol estrogen ethanol ft4 highlights hydroxytamoxifen interfere menopausal modulated mu pgr plus postmenopausal progesterone tgfa tgfb1 thra thyroid tpo triiodothyronine tsh upregulated verified
Tagcloud (Difference) ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome serpini1 silac silico sostdc1 spectrometer tumorigenic velos zg16b	ab block bmp brc differ downregulated estradiol estrogen ethanol ft4 highlights hydroxytamoxifen interfere menopausal modulated mu pgr plus postmenopausal progesterone tgfa tgfb1 thra thyroid tpo triiodothyronine tsh upregulated verified
Tagcloud (Intersection) ?