PDXK and GET1

		PDXK	GET1
Description		pyridoxal kinase	guided entry of tail-anchored proteins factor 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Secretory Granule Lumen Specific Granule Lumen Extracellular Exosome	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding ATP Binding Zinc Ion Binding Pyridoxal Kinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Pyridoxal Phosphate Binding Potassium Ion Binding Sodium Ion Binding Lithium Ion Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding Protein-membrane Adaptor Activity
	Biological Process	Pyridoxal 5'-phosphate Salvage Pyridoxal Metabolic Process Pyridoxamine Metabolic Process Pyridoxal Phosphate Metabolic Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane
Pathways		Neutrophil degranulation Vitamin B6 activation to pyridoxal phosphate	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Pyridoxal Pyridoxine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		2 interacting genes: BARD1 YWHAQ	28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42
Entrez ID		8566	7485
HPRD ID		01526	04224
Ensembl ID		ENSG00000160209	ENSG00000182093
Uniprot IDs		F2Z2Y4 O00764 V9HWC3	O00258
PDB IDs		2AJP 2F7K 2YXT 2YXU 3FHX 3FHY 3KEU 4EN4 4EOH 8WR2	6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex GET Complex Positive Regulation Of Interleukin-6-mediated Signaling Pathway Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process BRCA1-A Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Protein Targeting Otic Vesicle Development Ripoptosome Positive Regulation Of MiRNA Processing JUN Kinase Kinase Kinase Activity Necroptotic Signaling Pathway Death-inducing Signaling Complex Peptidyl-serine Autophosphorylation Positive Regulation Of Necroptotic Process Regulation Of MRNA 3'-end Processing Positive Regulation Of Programmed Necrotic Cell Death Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Transport Regulation Of Phosphorylation DNA Strand Resection Involved In Replication Fork Processing Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Macrophage Differentiation Regulation Of MiRNA Processing Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Necroptotic Process Regulation Of Regulatory NcRNA Processing Death Receptor Binding Intracellular Signal Transduction Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Negative Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Checkpoint Protein Targeting To ER	Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex
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