PDXK

Description		pyridoxal kinase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Secretory Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding ATP Binding Zinc Ion Binding Pyridoxal Kinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Pyridoxal Phosphate Binding Potassium Ion Binding Sodium Ion Binding Lithium Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Pyridoxal 5'-phosphate Salvage Pyridoxal Metabolic Process Pyridoxamine Metabolic Process Pyridoxal Phosphate Metabolic Process
Pathways		Neutrophil degranulation Vitamin B6 activation to pyridoxal phosphate
Drugs		Pyridoxal Pyridoxine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Systolic blood pressure change trajectory ( 27980656)
Novel Interacting Genes		2 novel interacting genes: GET1 RIPK1
Interacting Genes		2 interacting genes: BARD1 YWHAQ
Entrez ID		8566
HPRD ID		01526
Ensembl ID		ENSG00000160209
Uniprot IDs		F2Z2Y4 O00764 V9HWC3
PDB IDs		2AJP 2F7K 2YXT 2YXU 3FHX 3FHY 3KEU 4EN4 4EOH 8WR2
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex GET Complex Positive Regulation Of Interleukin-6-mediated Signaling Pathway Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process BRCA1-A Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Protein Targeting Otic Vesicle Development Ripoptosome Positive Regulation Of MiRNA Processing JUN Kinase Kinase Kinase Activity Necroptotic Signaling Pathway Death-inducing Signaling Complex Peptidyl-serine Autophosphorylation Positive Regulation Of Necroptotic Process Regulation Of MRNA 3'-end Processing Positive Regulation Of Programmed Necrotic Cell Death Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Transport Regulation Of Phosphorylation DNA Strand Resection Involved In Replication Fork Processing Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Macrophage Differentiation Regulation Of MiRNA Processing Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Necroptotic Process Regulation Of Regulatory NcRNA Processing Death Receptor Binding Intracellular Signal Transduction Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Negative Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Checkpoint Protein Targeting To ER
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