PDXK

Gene Name		pyridoxal (pyridoxine, vitamin B6) kinase
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding ATP Binding Zinc Ion Binding Pyridoxal Kinase Activity Pyridoxal Phosphate Binding Potassium Ion Binding Sodium Ion Binding Lithium Ion Binding Protein Homodimerization Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Cell Proliferation Pyridoxal 5'-phosphate Salvage Phosphorylation Vitamin B6 Metabolic Process Pyridoxal Phosphate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Vitamins B6 activation to pyridoxal phosphate Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs		Pyridoxal Pyridoxine Adenosine-5\'-Diphosphate Adenosine-5\'-[Beta, Gamma-Methylene]Triphosphate O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL N6-METHYL-(R)-ROSCOVITINE, R-2-[6-(BENZYL-METHYL-AMINO)-9-ISOPROPYL-9H-PURIN-2-YLAMINO]-BUTAN-1-OL
Diseases
GWAS
Protein-protein Interactions		2 interactors: BARD1 YWHAQ
Entrez ID		8566
HPRD ID		01526
Ensembl ID		ENSG00000160209
Uniprot IDs		F2Z2Y4 O00764
PDB IDs		2AJP 2F7K 2YXT 2YXU 3FHX 3FHY 3KEU 4EN4 4EOH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MRNA 3'-end Processing Regulation Of Intracellular Transport Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Regulation Of MRNA 3'-end Processing Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cellular Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Export From Nucleus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Negative Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Cell Death Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Midbrain Development Negative Regulation Of Intracellular Protein Transport Regulation Of MRNA Processing Regulation Of Mitochondrion Organization Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Transport Cell Cycle Arrest Protein Polyubiquitination
Tagcloud ?		2ddm b6 belonged belongs catalysis catalyzes ccp4 crystallized diffraction excluding nta orthorhombic oscillation p212121 pdb phaser phasing phosphotransferase polycrystalline powder primitive pyridoxal pyridoxamine pyridoxine refinement reflections rings suite typhimurium