DOCK7 and RNF26

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		DOCK7	RNF26
Description		dedicator of cytokinesis 7	ring finger protein 26
Image			No pdb structure
GO Annotations	Cellular Component	Focal Adhesion COP9 Signalosome Axon Growth Cone Cell Projection Neuron Projection Basal Part Of Cell	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization Small GTPase-mediated Signal Transduction Nervous System Development Axonogenesis Rac Protein Signal Transduction Interkinetic Nuclear Migration Cell Differentiation Neuron Projection Development Regulation Of Rho Protein Signal Transduction Establishment Of Neuroblast Polarity Regulation Of Neurogenesis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		MET activates RAP1 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 19060911 28270201 25961943 20686565) Crohn's disease ( 28067908) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 20686565 25961943 30275531 19060911) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483 22916037) Platelet distribution width ( 32888494 27863252) Pneumococcal bacteremia ( 27236921) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels ( 33031748 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 29403010 33339817 30275531) Triglyceride levels ( 32154731 33339817 31170924 30698716 29615537 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 20686565 19060911 18193044 25961943) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 NOD2 NSD3 PPP2CB PRNP RAC1 RHOA RNF26 RPP14 SMN1 SNCA TK1 TRIM55 TRIM63 YWHAG	54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1
Entrez ID		85440	79102
HPRD ID		16833	05842
Ensembl ID		ENSG00000116641	ENSG00000173456
Uniprot IDs		Q96N67	Q9BY78
PDB IDs		6AJ4 6AJL
Enriched GO Terms of Interacting Partners?		Protein Kinase Binding Membrane Organization Negative Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Postsynapse Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell Activation Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Cellular Respiration Membrane Invagination Non-canonical Wnt Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Identical Protein Binding Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein Sequestering Activity Regulation Of Microtubule Polymerization Cuprous Ion Binding G Protein Activity Regulation Of Synaptic Plasticity Negative Regulation Of Signal Transduction Focal Adhesion Regulation Of Protein-containing Complex Assembly Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cytoplasmic Ribonucleoprotein Granule Regulation Of Protein Metabolic Process Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Cytoplasm Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Hydrogen Peroxide Metabolic Process Response To Lipid Regulation Of Neuron Apoptotic Process Regulation Of Stress Fiber Assembly Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Microtubule-based Process Small GTPase-mediated Signal Transduction	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation
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