DOCK7 and RPP14

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DOCK7	RPP14
Gene Name		dedicator of cytokinesis 7	ribonuclease P/MRP 14kDa subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Focal Adhesion COP9 Signalosome Axon Growth Cone Neuron Projection Basal Part Of Cell	Nucleus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding	RNA Binding Ribonuclease P Activity
	Biological Process	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Small GTPase Mediated Signal Transduction Axonogenesis Interkinetic Nuclear Migration Neuron Projection Development Activation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Pigmentation Establishment Of Neuroblast Polarity Regulation Of Neurogenesis	TRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 19060911 20686565) Metabolite levels ( 22916037) Triglycerides ( 18193044 20864672 19060911 20686565)
Protein-Protein Interactions		13 interactors: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 PPP2CB RHOA RPP14 SMN1 SNCA TK1 WHSC1L1 YWHAG	19 interactors: A2M ATP5B CAPZB DOCK7 EXOSC8 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ
Entrez ID		85440	11102
HPRD ID		16833	18001
Ensembl ID		ENSG00000116641	ENSG00000163684
Uniprot IDs		Q96N67 Q96NI0	O95059
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Regulation Of Protein Localization Organelle Organization Hemostasis Response To Organic Cyclic Compound Response To Copper Ion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Inorganic Substance Apoptotic Process Response To Toxic Substance Response To Stress Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Death Death Substantia Nigra Development Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Response To External Stimulus Positive Regulation Of Cytokinesis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Process Response To Growth Factor Cellular Response To Organic Substance Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Intracellular Protein Transport Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Neural Nucleus Development Cellular Response To Ionizing Radiation Positive Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Neuron Death Regulation Of Cytokinesis Regulation Of Signaling	RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Phosphodiester Bond Hydrolysis TRNA Processing TRNA Metabolic Process NcRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Reciprocal Meiotic Recombination Negative Regulation Of Complement Activation, Lectin Pathway Ribonucleoprotein Complex Biogenesis Meiotic Mismatch Repair Establishment Of Neuroblast Polarity Mitotic DNA Damage Checkpoint Cellular Metabolic Process Mitotic DNA Integrity Checkpoint Gene Silencing Meiotic Gene Conversion Maintenance Of DNA Repeat Elements Positive Regulation Of Gene Silencing By MiRNA Generation Of Precursor Metabolites And Energy Signal Transduction By P53 Class Mediator Positive Regulation Of Nuclear Cell Cycle DNA Replication
Tagcloud ?		2510dela 3709c 6232g 983c abolish arg1237 asp837alafs blindness dysmorphic encephalopathies epileptic exome gabaergic genesis glu2078 heterozygotes hyperintensities interneurons intractable nonconsanguineous pontobulbar proband rac sanger ser328 sisters sulcus syndromic truncating
Tagcloud (Difference) ?		2510dela 3709c 6232g 983c abolish arg1237 asp837alafs blindness dysmorphic encephalopathies epileptic exome gabaergic genesis glu2078 heterozygotes hyperintensities interneurons intractable nonconsanguineous pontobulbar proband rac sanger ser328 sisters sulcus syndromic truncating
Tagcloud (Intersection) ?