DOCK7 and ANXA7

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DOCK7	ANXA7
Gene Name		dedicator of cytokinesis 7	annexin A7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Focal Adhesion COP9 Signalosome Axon Growth Cone Neuron Projection Basal Part Of Cell	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Chromaffin Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding	Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Small GTPase Mediated Signal Transduction Axonogenesis Interkinetic Nuclear Migration Neuron Projection Development Activation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Pigmentation Establishment Of Neuroblast Polarity Regulation Of Neurogenesis	Cellular Calcium Ion Homeostasis Autophagy Hemostasis Cell Proliferation Regulation Of Cell Shape Response To Salt Stress Cellular Water Homeostasis Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Social Behavior Response To Calcium Ion Membrane Fusion
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 19060911 20686565) Metabolite levels ( 22916037) Triglycerides ( 18193044 20864672 19060911 20686565)
Protein-Protein Interactions		13 interactors: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 PPP2CB RHOA RPP14 SMN1 SNCA TK1 WHSC1L1 YWHAG	108 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CPSF3L CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TP53 TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		85440	310
HPRD ID		16833	01720
Ensembl ID		ENSG00000116641	ENSG00000138279
Uniprot IDs		Q96N67 Q96NI0	B2R657 P20073
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Regulation Of Protein Localization Organelle Organization Hemostasis Response To Organic Cyclic Compound Response To Copper Ion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Inorganic Substance Apoptotic Process Response To Toxic Substance Response To Stress Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Death Death Substantia Nigra Development Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Response To External Stimulus Positive Regulation Of Cytokinesis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Process Response To Growth Factor Cellular Response To Organic Substance Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Intracellular Protein Transport Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Neural Nucleus Development Cellular Response To Ionizing Radiation Positive Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Neuron Death Regulation Of Cytokinesis Regulation Of Signaling	Anatomical Structure Development Multicellular Organismal Development Developmental Process System Development Cellular Metabolic Process Metabolic Process Cellular Response To Organic Substance Platelet Activation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Blood Coagulation Response To Growth Factor Programmed Cell Death Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Cell Death Catabolic Process Death Response To Organic Substance Apoptotic Process Histone H3-T6 Phosphorylation Regulation Of Apoptotic Process Nervous System Development Regulation Of Body Fluid Levels Negative Regulation Of Protein Metabolic Process Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Proteolysis Mitotic Cell Cycle Process Negative Regulation Of Glucose Transport Organelle Organization Cell Activation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Cellular Process Regulation Of Cellular Response To Insulin Stimulus Wound Healing Cellular Response To Stimulus Regulation Of Proteasomal Protein Catabolic Process Gene Expression Protein Metabolic Process Mitotic Cell Cycle Organ Development Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization
Tagcloud ?		2510dela 3709c 6232g 983c abolish arg1237 asp837alafs blindness dysmorphic encephalopathies epileptic exome gabaergic genesis glu2078 heterozygotes hyperintensities interneurons intractable nonconsanguineous pontobulbar proband rac sanger ser328 sisters sulcus syndromic truncating	annexin anticancer antitumor chinese cytotoxic cytotoxicity decreasing depressed dramatically eecp ethanol exerted explored huvecs kappa mb mcf mda mitochondrial mu obviously p65 possess propolis ros umbilical upregulating vein
Tagcloud (Difference) ?		2510dela 3709c 6232g 983c abolish arg1237 asp837alafs blindness dysmorphic encephalopathies epileptic exome gabaergic genesis glu2078 heterozygotes hyperintensities interneurons intractable nonconsanguineous pontobulbar proband rac sanger ser328 sisters sulcus syndromic truncating	annexin anticancer antitumor chinese cytotoxic cytotoxicity decreasing depressed dramatically eecp ethanol exerted explored huvecs kappa mb mcf mda mitochondrial mu obviously p65 possess propolis ros umbilical upregulating vein
Tagcloud (Intersection) ?