DOCK7

Gene Name		dedicator of cytokinesis 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Focal Adhesion COP9 Signalosome Axon Growth Cone Neuron Projection Basal Part Of Cell
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding
	Biological Process	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Small GTPase Mediated Signal Transduction Axonogenesis Interkinetic Nuclear Migration Neuron Projection Development Activation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Pigmentation Establishment Of Neuroblast Polarity Regulation Of Neurogenesis
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 19060911 20686565) Metabolite levels ( 22916037) Triglycerides ( 18193044 20864672 19060911 20686565)
Protein-protein Interactions		13 interactors: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 PPP2CB RHOA RPP14 SMN1 SNCA TK1 WHSC1L1 YWHAG
Entrez ID		85440
HPRD ID		16833
Ensembl ID		ENSG00000116641
Uniprot IDs		Q96N67 Q96NI0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Regulation Of Protein Localization Organelle Organization Hemostasis Response To Organic Cyclic Compound Response To Copper Ion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Inorganic Substance Apoptotic Process Response To Toxic Substance Response To Stress Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Death Death Substantia Nigra Development Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Response To External Stimulus Positive Regulation Of Cytokinesis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Process Response To Growth Factor Cellular Response To Organic Substance Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Intracellular Protein Transport Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Neural Nucleus Development Cellular Response To Ionizing Radiation Positive Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Neuron Death Regulation Of Cytokinesis Regulation Of Signaling
Tagcloud ?		2510dela 3709c 6232g 983c abolish arg1237 asp837alafs blindness dysmorphic encephalopathies epileptic exome gabaergic genesis glu2078 heterozygotes hyperintensities interneurons intractable nonconsanguineous pontobulbar proband rac sanger ser328 sisters sulcus syndromic truncating