DOCK7

Description		dedicator of cytokinesis 7
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GO Annotations	Cellular Component	Focal Adhesion COP9 Signalosome Axon Growth Cone Cell Projection Neuron Projection Basal Part Of Cell
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Microtubule Cytoskeleton Organization Small GTPase-mediated Signal Transduction Nervous System Development Axonogenesis Rac Protein Signal Transduction Interkinetic Nuclear Migration Cell Differentiation Neuron Projection Development Regulation Of Rho Protein Signal Transduction Establishment Of Neuroblast Polarity Regulation Of Neurogenesis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		MET activates RAP1 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 19060911 28270201 25961943 20686565) Crohn's disease ( 28067908) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 20686565 25961943 30275531 19060911) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483 22916037) Platelet distribution width ( 32888494 27863252) Pneumococcal bacteremia ( 27236921) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels ( 33031748 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 29403010 33339817 30275531) Triglyceride levels ( 32154731 33339817 31170924 30698716 29615537 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 20686565 19060911 18193044 25961943) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		19 interacting genes: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 NOD2 NSD3 PPP2CB PRNP RAC1 RHOA RNF26 RPP14 SMN1 SNCA TK1 TRIM55 TRIM63 YWHAG
Entrez ID		85440
HPRD ID		16833
Ensembl ID		ENSG00000116641
Uniprot IDs		Q96N67
PDB IDs		6AJ4 6AJL
Enriched GO Terms of Interacting Partners?		Protein Kinase Binding Membrane Organization Negative Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Postsynapse Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell Activation Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Cellular Respiration Membrane Invagination Non-canonical Wnt Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Identical Protein Binding Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein Sequestering Activity Regulation Of Microtubule Polymerization Cuprous Ion Binding G Protein Activity Regulation Of Synaptic Plasticity Negative Regulation Of Signal Transduction Focal Adhesion Regulation Of Protein-containing Complex Assembly Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cytoplasmic Ribonucleoprotein Granule Regulation Of Protein Metabolic Process Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Cytoplasm Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Hydrogen Peroxide Metabolic Process Response To Lipid Regulation Of Neuron Apoptotic Process Regulation Of Stress Fiber Assembly Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Microtubule-based Process Small GTPase-mediated Signal Transduction
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