DOCK7 and NSD3

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		DOCK7	NSD3
Description		dedicator of cytokinesis 7	nuclear receptor binding SET domain protein 3
Image
GO Annotations	Cellular Component	Focal Adhesion COP9 Signalosome Axon Growth Cone Cell Projection Neuron Projection Basal Part Of Cell	Chromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3K27 Methyltransferase Activity Transcription Regulator Activator Activity Histone H3 Methyltransferase Activity Histone H3K4 Dimethyltransferase Activity Histone H3K27 Trimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity
	Biological Process	Microtubule Cytoskeleton Organization Small GTPase-mediated Signal Transduction Nervous System Development Axonogenesis Rac Protein Signal Transduction Interkinetic Nuclear Migration Cell Differentiation Neuron Projection Development Regulation Of Rho Protein Signal Transduction Establishment Of Neuroblast Polarity Regulation Of Neurogenesis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of DNA-templated Transcription
Pathways		MET activates RAP1 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 19060911 28270201 25961943 20686565) Crohn's disease ( 28067908) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 20686565 25961943 30275531 19060911) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483 22916037) Platelet distribution width ( 32888494 27863252) Pneumococcal bacteremia ( 27236921) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels ( 33031748 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 29403010 33339817 30275531) Triglyceride levels ( 32154731 33339817 31170924 30698716 29615537 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 20686565 19060911 18193044 25961943) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		19 interacting genes: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 NOD2 NSD3 PPP2CB PRNP RAC1 RHOA RNF26 RPP14 SMN1 SNCA TK1 TRIM55 TRIM63 YWHAG	41 interacting genes: AKT1 ATM BCAR3 CASP8 CBLC CBX3 CBX5 CDKN2A CHEK2 DAXX DOCK7 ESR1 ETV3 FGFR4 GLIS2 GLYR1 H1-1 H3-5 H3C1 H4C1 HOXC4 MLLT6 MNDA NFIC PAX2 PPM1D RB1CC1 SEPTIN6 SLU7 SOX3 SOX4 SPAG8 STAC3 TCF3 TEAD2 TERT TGFB1 TRIM55 TRIM63 UBE2I ZNF557
Entrez ID		85440	54904
HPRD ID		16833	06155
Ensembl ID		ENSG00000116641	ENSG00000147548
Uniprot IDs		Q96N67	Q9BZ95
PDB IDs		6AJ4 6AJL	2DAQ 2NCZ 2ND1 4GND 4GNE 4GNF 4GNG 4RXJ 5UPD 6CEN 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P 6G3T 7CRP 7CRQ 7CRR 7JYN
Enriched GO Terms of Interacting Partners?		Protein Kinase Binding Membrane Organization Negative Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Postsynapse Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell Activation Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Cellular Respiration Membrane Invagination Non-canonical Wnt Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Identical Protein Binding Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein Sequestering Activity Regulation Of Microtubule Polymerization Cuprous Ion Binding G Protein Activity Regulation Of Synaptic Plasticity Negative Regulation Of Signal Transduction Focal Adhesion Regulation Of Protein-containing Complex Assembly Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cytoplasmic Ribonucleoprotein Granule Regulation Of Protein Metabolic Process Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Cytoplasm Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Hydrogen Peroxide Metabolic Process Response To Lipid Regulation Of Neuron Apoptotic Process Regulation Of Stress Fiber Assembly Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Microtubule-based Process Small GTPase-mediated Signal Transduction	Nucleus Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Replicative Senescence Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process PML Body Euchromatin Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Protein K63-linked Ubiquitination Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Chromosome, Telomeric Region Cellular Developmental Process Chromatin Remodeling DNA-binding Transcription Factor Activity Pexophagy Negative Regulation Of B Cell Proliferation
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